Estramustin HEXAL

Estramustin HEXAL Uses, Dosage, Side Effects, Food Interaction and all others data.

A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.

Estramustin HEXAL is an antineoplastic agent indicated in the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate. Estramustin HEXAL is a combination of estradiol with nitrogen mustard. In vivo, the nitrogen-mustard moiety becomes active and participates in alkylation of DNA or other cellular components.. This causes DNA damage in rapidly dividing cancerous cells leading to cell death and ideally, tumor shrinkage.

Estramustin HEXAL
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Estramustin HEXAL
Availability	Prescription only
Generic	Estramustine
Estramustine Other Names	Estramustina, Estramustine, Estramustinum
Related Drugs	estradiol, Premarin, Xtandi, Casodex, Zytiga, Lynparza
Type
Formula	C₂₃H₃₁Cl₂NO₃
Weight	Average: 440.403 Monoisotopic: 439.168099277
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	Germany
Last Updated:	September 19, 2023 at 7:00 am

Uses

Estramustin HEXAL is an antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting.

For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate

Estramustin HEXAL is also used to associated treatment for these conditions: Metastatic Hormone Refractory Prostate Cancer

How Estramustin HEXAL works

Estramustin HEXAL is a derivative of estradiol with a nitrogen mustard moiety. This gives it alkylating properties. In vivo, the nitrogen mustard component is active and can alklyate DNA and other cellular components (such as tubulin components) of rapidly dividing cells. This causes DNA strandbreaks or misscoding events. This leads to apoptosis and cell death. Also, due to the drugs estrogen component, it can bind more selectively to active estrogen receptors.

Food Interaction

Avoid milk and dairy products.
Take on an empty stomach.

[Moderate] ADJUST DOSING INTERVAL: Food and milk may significantly decrease serum concentrations of estramustine.

The mechanism of the interaction is not known.

MANAGEMENT: It is recommended that estramustine be taken at least 1 hour before or 2 hours after meals, and that it not be coadministered with milk, or calcium containing products.

Estramustin HEXAL Hypertension interaction

[Major] The risk of myocardial infarction and strokes, including those associated with estrogen use, may be increased in patients with hypertension.

Moreover, estramustine may elevate blood pressure and worsen the hypertension, thus compounding the risk.

Therapy with estramustine should be administered cautiously in patients with preexisting hypertension.

Patients should be monitored for changes in cardiovascular status, and their antihypertensive regimen adjusted as necessary.

Estramustin HEXAL Disease Interaction

Major: hypertension, thromboembolism/cardiovascular, abnormal vaginal bleeding, hypercalcemia in breast cancerModerate: hypercalcemia, liver disease, fluid retention, glucose intolerance, thyroid function tests

Half Life

20 hours

Elimination Route

The metabolic urinary patterns of the estradiol moiety of estramustine phosphate and estradiol itself are very similar, although the metabolites derived from estramustine phosphate are excreted at a slower rate.