Ethacrynic Sodium

Ethacrynic Sodium Uses, Dosage, Side Effects, Food Interaction and all others data.

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

Ethacrynic acid is a monosulfonamyl loop or high ceiling diuretic. Ethacrynic acid acts on the ascending limb of the loop of Henle and on the proximal and distal tubules. Urinary output is usually dose dependent and related to the magnitude of fluid accumulation. Water and electrolyte excretion may be increased several times over that observed with thiazide diuretics, since ethacrynic acid inhibits reabsorption of a much greater proportion of filtered sodium than most other diuretic agents. Therefore, ethacrynic acid is effective in many patients who have significant degrees of renal insufficiency. Ethacrynic acid has little or no effect on glomerular filtration or on renal blood flow, except following pronounced reductions in plasma volume when associated with rapid diuresis.

Ethacrynic Sodium
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Ethacrynic Sodium
Generic	Etacrynic acid
Etacrynic acid Other Names	Acide étacrynique, ácido etacrínico, Acidum etacrynicum, Etacrinic acid, Etacrynic acid, Ethacrynate, Ethacrynic acid, Methylenebutyrylphenoxyacetic acid
Type
Formula	C₁₃H₁₂Cl₂O₄
Weight	Average: 303.138 Monoisotopic: 302.011264286
Protein binding	> 98%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	USA
Last Updated:	September 19, 2023 at 7:00 am

Uses

Ethacrynic Sodium is a diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease.

For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.

Ethacrynic Sodium is also used to associated treatment for these conditions: Ascites, Congenital Heart Disease (CHD), Edema, Nephrotic Syndrome

How Ethacrynic Sodium works

Ethacrynic acid inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. Diuretics also lower blood pressure initially by reducing plasma and extracellular fluid volume; cardiac output also decreases, explaining its antihypertensive action. Eventually, cardiac output returns to normal with an accompanying decrease in peripheral resistance. Its mode of action does not involve carbonic anhydrase inhibition.

Toxicity

Overdosage may lead to excessive diuresis with electrolyte depletion.

Food Interaction

Take with food. Food reduces irritation.

Elimination Route

Onset of action is rapid, usually within 30 minutes after an oral dose of ethacrynic acid or within 5 minutes after an intravenous injection of ethacrynic acid.