Ethinyl Estradiol And Norgestrel

Ethinyl Estradiol And Norgestrel Uses, Dosage, Side Effects, Food Interaction and all others data.

Norgestrel (and more specifically the active stereoisomer levonorgestrel) binds to the progesterone and estrogen receptors within the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. Loss of the LH surge inhibits ovulation and thereby prevents pregnancy.

Trade Name Ethinyl Estradiol And Norgestrel
Generic Ethinyl estradiol + norgestrel
Weight 30mcg + 0.3mg, 50mcg + 0.5mg
Type Oral tablet
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Ethinyl Estradiol And Norgestrel
Ethinyl Estradiol And Norgestrel

Uses

Norgestrel in combination with ethinyl estradiol is used for the prevention of pregnancy in women who elect to use this product as a method of contraception.

Ethinyl Estradiol And Norgestrel is also used to associated treatment for these conditions: Abnormal Uterine Bleeding, Endometriosis, Hypermenorrhea, Menstrual Distress (Dysmenorrhea), Polycystic Ovarian Syndrome, Emergency Contraception, Oral Contraceptives

How Ethinyl Estradiol And Norgestrel works

Norgestrel (and more specifically the active stereoisomer levonorgestrel) binds to the progesterone and estrogen receptors within the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. Loss of the LH surge inhibits ovulation and thereby prevents pregnancy.

Dosage

Ethinyl Estradiol And Norgestrel dosage

0.075 mg at same time each day

Side Effects

Edema, Weakness, Anorexia, Amenorrhea, Breakthrough bleeding, Change in menstrual flow, Spotting

Precaution

  • Documented hypersensitivity
  • Active or history of breast cancer
  • Thrombophlebitis, DVT/PE, thrombogenic valvular disease
  • Estrogen-dependent neoplasia
  • Liver disease, liver tumors
  • Undiagnosed abnormal vaginal bleeding, uncontrolled hypertension, diabetes mellitus with vascular involvement, jaundice with prior oral contraceptive use, pregnancy, smoking >15 cigarettes/d) and >35 yo, history of migraine w/ aura
  • Serum levels near baseline 24 hr after ingestion, so rigid adherence to dosing schedule is essential for efficacy
  • DM, asthma, cardiac dysfunction, irregular menstrual bleeding patterns, bone mineral density changes, depression, epilepsy, migraine, renal dysfunction
  • Risk of ectopic pregnancy is 0.5%

Pregnancy & Breastfeeding use

Pregnancy Category: X

Lactation: unsafe

Contraindication

  • Documented hypersensitivity
  • Active or history of breast cancer
  • Arterial thromboembolic disease (stroke, MI), thrombophlebitis, DVT/PE, thrombogenic valvular disease
  • Estrogen-dependent neoplasia
  • Liver disease, liver tumors
  • Undiagnosed abnormal vaginal bleeding
  • Uncontrolled hypertension
  • Diabetes mellitus with vascular involvement
  • Jaundice with prior oral contraceptive use, pregnancy, smoking >15 cigarettes/d) and >35 yo, history of migraine with aura
  • Pregnancy or use as a diagnostic test for pregnancy

Storage Condition

Should be stored in cool and dry place

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*** Taking medicines without doctor's advice can cause long-term problems.
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