Ethirov

Ethirov Uses, Dosage, Side Effects, Food Interaction and all others data.

Ethirov is a macrolide antibacterial that inhibits protein synthesis by irreversibly binding to the 50S subunit of the ribosomal subunit thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.

The absolute bioavailability of oral spiramycin is generally within the range of 30 to 40%. After a 1 g oral dose, the maximum serum drug concentration was found to be within the range 0.4 to 1.4 mg/L.

Trade Name Ethirov
Generic Spiramycin
Spiramycin Other Names Demycarosylturimycin H, Foromacidin A, Foromacidine A, Spiramycin 1, Spiramycin A, Spiramycin I
Type
Formula C43H74N2O14
Weight Average: 843.065
Monoisotopic: 842.514005071
Protein binding

Low level of protein binding (10-25%).

Groups Approved
Therapeutic Class Macrolides
Manufacturer
Available Country Indonesia
Last Updated: September 19, 2023 at 7:00 am
Ethirov
Ethirov

Uses

Acne vulgaris, Cryptosporidiosis, Protozoal infections, Susceptible infections, Toxoplasmosis

Ethirov is also used to associated treatment for these conditions: Bacterial Infections

How Ethirov works

The mechanism of action of macrolides has been a matter of controversy for some time. Ethirov, a 16-membered macrolide, inhibits translocation by binding to bacterial 50S ribosomal subunits with an apparent 1 : 1 stoichiometry. This antibiotic is a potent inhibitor of the binding to the ribosome of both donor and acceptor substrates. The primary mechanism of action is done by stimulation of dissociation of peptidyl-tRNA from ribosomes during translocation.I

Dosage

Ethirov dosage

Intravenous-

Toxoplasmosis, Cryptosporidiosis, Protozoal infections, Susceptible infections:

  • Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections.

Oral-Cryptosporidiosis, Protozoal infections, Susceptible infections, Toxoplasmosis:

  • Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.
  • Child and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid.

May be taken with or without food.

Side Effects

Nausea, vomiting, abdominal pain, diarrhoea; urticaria, pruritus, macular rashes. Transient paraesthesia may occur.

Toxicity

Cardiac toxicity, specifically QT prolongation (irregular heartbeat; recurrent fainting).
Cholestatic hepatitis (abdominal pain; nausea; vomiting; yellow eyes or skin).
Gastrointestinal toxicity, specifically acute colitis (abdominal pain and tenderness; bloody stools; fever).
Intestinal injury (abdominal pain and tenderness). Ulcerated esophagitis (chest pain; heartburn).

Precaution

Hepatic impairment; pregnancy and lactation. Monitor liver function. History of arrhythmias or predisposition to QT interval prolongation.

Interaction

Decreases carbidopa absorption and levodopa concentrations. Increased risk of ventricular arrhythmias when used with astemizole, cisapride and terfenadine. Risk of acute dystonia when used with fluphenazine

Food Interaction

  • No food interactions are expected.

Volume of Distribution

The tissue distribution of spiramycin is extensive. The volume of distribution is in excess of 300 L, and concentrations achieved in bone, muscle, respiratory tract and saliva exceed those found in serum. Ethirov showed high concentrations in tissues such as: lungs, bronchi, tonsils, and sinuses.

Elimination Route

The extent of absorption of Ethirov was shown to be incomplete. Oral bioavailability ranges from 30-39%. Ethirov has slower rate of absorption than Erythromycin. It has a high pKa (7.9) which could be a result of high degree of ionization in acidic medium of the stomach.

Half Life

Intravenous: Young persons (18 to 32 years of age): Approximately 4.5 to 6.2 hours. Elderly persons (73 to 85 years of age): Approximately 9.8 to 13.5 hours.

Oral: 5.5-8 hours, Rectal in children: 8 hours

Clearance

80% of the administered dose excreted in the bile, which makes the fecal-biliary route is the most important route of elimination. Enterohepatic recycling could also occur. Only 4 to 14% of an administered dose is eliminated through renal-urinary excretion route.

Elimination Route

Fecal-biliary route is the primary route of elimination. The secondary route is renal-urinary route.

Pregnancy & Breastfeeding use

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Contraindication

Hypersensitivity.

Innovators Monograph

You find simplified version here Ethirov

Ethirov contains Spiramycin see full prescribing information from innovator Ethirov Monograph, Ethirov MSDS, Ethirov FDA label

FAQ

What is Ethirov used for?

Ethirov is used to treat a wide variety of bacterial infections. This medication is known as a macrolide antibiotic.Ethirov works by stopping the growth of bacteria. This antibiotic treats only bacterial infections.

How safe is Ethirov?

Ethirov 1.5 mg tablet is safe for kidney disease patients to use. No dosage change is recommended for the Ethirov 1.5mg Tablet. Liver - Consult the physician Limited information on the use of the Ethirov 1.5mg tablet in patients with liver disease is available.

What are the common side effects of Ethirov?

Indigestion, nausea, vomiting, diarrhea or stomach ache may occur. If any of these effects continue or become bothersome, inform your doctor. In the unlikely event you have an allergic reaction to this drug, seek medical attention immediately.

Is Ethirov safe during pregnancy?

Yes, Ethirov is safe to use in pregnancy. Ethirov is considered safe to use during pregnancy. Animal studies have shown little to no adverse effects on the developing baby; human studies, however, are minimal.

Is Ethirov safe during pregnancy?

Ethirov has less side effects and is recommended during breastfeeding period.

Is Ethirov a penicillin?

Ethirov proved to be equivalent to penicillin in the treatment of acute bacterial tonsillitis in adults.

Can I drive after taking Ethirov?

Ethirov normally does not affect your driving performance.

Does Ethirov cross placenta?

Ethirov is a macrolide antibiotic, which aims at the prevention of fetal infection. It does not cross the blood-placental barrier and, therefore, has no teratogenic effects to the fetus, or toxicity to the mother.

When is the best time to take Ethirov?

Ethirov is best taken on an empty stomach. To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if you begin to feel better after a few days.

How to take Ethirov?

Tell your doctor if you have ever had any unusual or allergic reaction to Ethirov or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Is there any food or drink I need to avoid when taking Ethirov?

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

How to proper use of Ethirov?

Ethirov is best taken on an empty stomach.To help clear up your infection completely, keep taking Ethirov for the full time of treatment, even if you begin to feel better after a few days. If you stop taking Ethirov too soon, your symptoms may return.

What happens if I miss a dose of Ethirov?

If you miss a dose of  Ethirov, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

What happen if I overdose of Ethirov?

Symptoms of overdose may include nausea, vomiting, and diarrhea.

Is Ethirov an antibiotic?

Ethirov is a macrolide antibiotic, first isolated from Streptomyces ambofaciens.

Is spiramycin broad spectrum?

Ethirov is a broad-spectrum macrolide antibiotic effective against gram-negative and gram-positive bacteria as well as some Toxoplasma parasites. Ethirov is a mixture of Ethirov I, II, and III and has been used to study sepsis in mice.

*** Taking medicines without doctor's advice can cause long-term problems.
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