Ethoxzolamide
Ethoxzolamide Uses, Dosage, Side Effects, Food Interaction and all others data.
Ethoxzolamide is a sulfonamide used as diuretic and in glaucoma. It inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. Its pharmacological activity thus confers the risk for hypokalemia.
Ethoxzolamide is an inhibitor of the carbonic anhydrase enzyme in proximal renal tubules that works by decreasing the reabsorption of water, sodium, potassium, bicarbonate. It also decreases the activity of carbonic anhydrase expressed in the CNS, which leads to increased seizure threshold. Inhibition of carbonic anhydrase in the eye contributes to its effect of reducing intraocular pressure and decreasing aqueous humor.
| Trade Name | Ethoxzolamide |
| Generic | Ethoxzolamide |
| Ethoxzolamide Other Names | Ethoxazolamide, Ethoxyzolamide |
| Type | |
| Formula | C9H10N2O3S2 |
| Weight | Average: 258.317 Monoisotopic: 258.013283576 |
| Protein binding | ~89% |
| Groups | Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy.
How Ethoxzolamide works
Ethoxzolamide binds to and inhibits carbonic anhydrase I, which plays an essential role in facilitating the transport of CO2 and H+ in the intracellular space, across biological membranes, and in the layers of the extracellular space. Through inhibition of the enzyme, the balance of applicable membrane equilibrium systems are affected.
Elimination Route
Rapidly absorbed with 65% bioavailability
Half Life
2.5-5.5 hours
Innovators Monograph
You find simplified version here Ethoxzolamide
