Ethylhexyl P-methoxycinnamate

Ethylhexyl P-methoxycinnamate Uses, Dosage, Side Effects, Food Interaction and all others data.

Ethylhexyl P-methoxycinnamate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage. It was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun. It is often combined with nanoparticles or other water-resistant liposomes in formulations to increase the localization at the epidermis and decrease the risk of percutaneous absorption. Its use in pharmaceutical and cosmetic formulations is approved by FDA.

Acts as a photoprotective agent that protects the skin by preventing and minimizing the damaging effects of ultraviolet (UV) rays of natural light. The cellular effects of UV irradiation include DNA damage, cell cycle arrest, immunological depression, apoptosis, and transcriptional changes .

Ethylhexyl P-methoxycinnamate
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Ethylhexyl P-methoxycinnamate
Generic	Octinoxate
Octinoxate Other Names	ethylhexyl methoxycinnamate, ethylhexyl p-methoxycinnamate, Octinoxate, octyl methoxycinnamate, parsol
Type
Formula	C₁₈H₂₆O₃
Weight	Average: 290.3972 Monoisotopic: 290.188194698
Protein binding	None
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Ethylhexyl P-methoxycinnamate is a sunscreen agent found in sunscreens that absorbs UV rays.

As an active ingredient in sunscreens and lip balms. Used for protection against damaging effects of sun rays.

Ethylhexyl P-methoxycinnamate is also used to associated treatment for these conditions: Sunburn

How Ethylhexyl P-methoxycinnamate works

Absorbs UV-B (predominantly) and UV-A rays while accumulating in the outermost layer of the epidermis. Like any other photoprotective agents, octinoxate prevents the damage to cells and deoxyribonucleic acid (DNA) by reducing the p53 protein expression following UV exposure and also increases the skin's tolerability to UV rays .

Toxicity

Slightly hazardous in case of skin contact, eye contact, ingestion and inhalation. Ethylhexyl P-methoxycinnamate may form reactive singlet oxygen species and induce anti-estrogenic effects . UV-induced molecular breakdown of octinoxate may interfere with cellular processes or induce oxidative damage in human skin . The NOAEL (no observed adverse effect level) is 450 mg/kg bw/day for fertility and reproductive performance, for systemic parental and developmental toxicity in Wistar rats .

Food Interaction

No interactions found.

Elimination Route

Can be systemically absorbed after skin application, being found in the deeper layers of the stratum corneum as well as urine, plasma, and breast milk . The mean maximum plasma concentration detected after application of 2mg/cm2 sunscreen was 7ng/mL in women and 16ng/mL in men .