Etos Wormkuurten Mebendazol

Etos Wormkuurten Mebendazol Uses, Dosage, Side Effects, Food Interaction and all others data.

Etos Wormkuurten Mebendazol is a synthetic derivative of benzimidazole with a potent anthelmintic activity against the most common nematodes and some cestodes. It is highly effective against ascariasis, enterobiasis, trichuriasis and hookworm infections. It is equally effective in single or in mixed infections. The effect of the drug is due to its ability to inhibit glucose uptake irreversibly but it does not affect blood glucose concentration in the host, even in high doses. Etos Wormkuurten Mebendazol does not necessitate any dosage calculation since the same dosage is used for children and adults. It can be taken at any time and no special procedures such as purging, use of laxatives and/or dietary changes are required. Parasite immobilization and death occur slowly and clearance from the gastro-intestinal tract may not be completed up to 3 days after administration.

Etos Wormkuurten Mebendazol is a (synthetic) broad-spectrum anthelmintic. The principal mode of action for Etos Wormkuurten Mebendazol is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.

Trade Name Etos Wormkuurten Mebendazol
Availability Prescription only
Generic Mebendazole
Mebendazole Other Names MBDZ, Mebendazol, Mébendazole, Mebendazole, Mebendazolum
Related Drugs metronidazole, Flagyl, albendazole, nitazoxanide, praziquantel, piperazine, pyrantel, Albenza, Alinia
Type
Formula C16H13N3O3
Weight Average: 295.2927
Monoisotopic: 295.095691297
Protein binding

90-95%

Groups Approved, Vet approved
Therapeutic Class Anti-helminthic
Manufacturer
Available Country Netherlands
Last Updated: September 19, 2023 at 7:00 am
Etos Wormkuurten Mebendazol
Etos Wormkuurten Mebendazol

Uses

Etos Wormkuurten Mebendazol is used for the treatment of pinworm (Enterobius vermicularis), round worm (Ascaris lumbricoides), hookworm (Ancylostoma duodenale and Necator americanus), whip worm (Trichuris trichiura), tape worm (Taenia solium and taenia saginata) and threadworm (Strongyloides stercoralis) in single or mixed infections

Etos Wormkuurten Mebendazol is also used to associated treatment for these conditions: Ancylostoma caninum infection, Ancylostoma duodenale infection, Ascaris lumbricoides infection, Capillariasis, Enterobius vermicularis infection, Filariasis, Giardiasis, Necatoriasis due to necator americanus, Strongyloides Stercoralis Infection, Taenia solium infection, Toxocariasis, Whipworm infection

How Etos Wormkuurten Mebendazol works

Etos Wormkuurten Mebendazol causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

Dosage

Etos Wormkuurten Mebendazol dosage

Etos Wormkuurten Mebendazol 100 mg tablet and suspension: This have the same dosage schedule applies to adults & children.

Enterobiasis: A single tablet or 1 teaspoonful of the suspension.

Ascariasis, Ancylostomiasis, Trichuriasis: 2 tablets, one in the morning, the other in the afternoon for 3 consecutive days or 1 teaspoonful in the morning & 1 teaspoonful in the afternoon for 3 consecutive days

Taeniasis & strongyloidiasis:

  • Adults: 2 tablets twice daily for 3 consecutive days.
  • Children: 1 tablet twice daily or 1 teaspoonful twice daily for 3 consecutive days.

Etos Wormkuurten Mebendazol 500 mg tablet: One Etos Wormkuurten Mebendazol 500 mg tablet in a single intake regardless of body weight, for all nematode and some cestode infestations. The same dosage applies to adults and children age two years and above.

May be taken with or without food.

Side Effects

Etos Wormkuurten Mebendazol is well tolerated by adults and children. It has virtually no side effects. Transient abdominal pain and diarrhoea have been reported only rarely, in case of massive infestation and expulsion of worms.

Toxicity

Acute oral toxicity (LD50): 620 mg/kg [Mouse]. Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.

Precaution

Hepatic impairment. Children. Pregnancy and lactation.

Interaction

Concomitant treatment with cimetidine may inhibit the metabolism of mebendazole in the liver, resulting in increased plasma concentrations of the drug especially during prolonged treatment.

Food Interaction

  • Take with or without food.

Etos Wormkuurten Mebendazol Disease Interaction

Moderate: liver disease

Elimination Route

Poorly absorbed (approximately 5 to 10%) from gastrointestinal tract. Fatty food increases absorption.

Half Life

2.5 to 5.5 hours (range 2.5 to 9 hours) in patients with normal hepatic function. Approximately 35 hours in patients with impaired hepatic function (cholestasis).

Elimination Route

In man, approximately 2% of administered mebendazole is excreted in urine and the remainder in the feces as unchanged drug or a primary metabolite.

Pregnancy & Breastfeeding use

Etos Wormkuurten Mebendazol should not be administered during pregnancy and in women thought to be pregnant. It is not known whether mebendazole or its metabolites are secreted in human breast milk. Thus Etos Wormkuurten Mebendazol should not be used during lactation unless the potential benefits are considered to outweigh the potential risk associated with treatment.

Contraindication

Etos Wormkuurten Mebendazol is contraindicated in pregnancy and in patients who have shown hypersensitivity to the product or any of its components.

Acute Overdose

Symptoms: Alopecia, reversible liver function disturbances, hepatitis, agranulocytosis, neutropenia, glomerulonephritis, abdominal cramps, nausea, vomiting and diarrhoea.

Management: Within the 1st hr after ingestion, gastric lavage may be performed. Activated charcoal may be given if considered appropriate.

Storage Condition

Store between 20-25° C.

Innovators Monograph

You find simplified version here Etos Wormkuurten Mebendazol

Etos Wormkuurten Mebendazol contains Mebendazole see full prescribing information from innovator Etos Wormkuurten Mebendazol Monograph, Etos Wormkuurten Mebendazol MSDS, Etos Wormkuurten Mebendazol FDA label

FAQ

What is Etos Wormkuurten Mebendazol used for?

Etos Wormkuurten Mebendazol is a medication used to treat a number of parasitic worm infestations. This includes ascariasis, pinworm infection, guinea worm infections, hydatid disease, and giardia, among others. Etos Wormkuurten Mebendazol also is used to treat: Common roundworms (ascariasis), Hookworms (ancylostomiasis, necatoriasis, uncinariasis).

How safe is Etos Wormkuurten Mebendazol?

Etos Wormkuurten Mebendazol generally safe. Taking an extra dose of Etos Wormkuurten Mebendazol by accident is unlikely to cause any harm.

How does Etos Wormkuurten Mebendazol work?

Etos Wormkuurten Mebendazol works by stopping the worms using sugar (glucose).

What are the common side effects of Etos Wormkuurten Mebendazol?

Common side effects of Etos Wormkuurten Mebendazol are include;

  • diarrhea.
  • stomach pain, discomfort, or swelling.
  • nausea.
  • vomiting.
  • loss of appetite.

Is Etos Wormkuurten Mebendazol safe during pregnancy?

Etos Wormkuurten Mebendazol are well tolerated, with no adverse events in pregnant women and their fetuses when given after the first trimester of pregnancy.

Is Etos Wormkuurten Mebendazol safe during breastfeeding?

Etos Wormkuurten Mebendazol use during lactation is considered to be safe due to a low oral absorption and unlikely excretion in milk.

Can I drink alcohol with Etos Wormkuurten Mebendazol ?

Yes, you can drink alcohol with Etos Wormkuurten Mebendazol.

When should be best taken of Etos Wormkuurten Mebendazol?

Etos Wormkuurten Mebendazol is best taken with meals, especially fatty ones (eg, meals that include whole milk or ice cream). This helps to clear up the infection by helping your body absorb the medicine better.

How many time can I take Etos Wormkuurten Mebendazol daily?

Usually you need to take a dose 2 times a day for 3 days.

How long does Etos Wormkuurten Mebendazol take to work?

Etos Wormkuurten Mebendazol should start to work straight away but it may take several days to kill all the worms.

How long does Etos Wormkuurten Mebendazol stay in my system?

The apparent elimination half-life after an oral dose ranges from 3 to 6 hours in most patients.

How long can I take Etos Wormkuurten Mebendazol?

Etos Wormkuurten Mebendazol is usually taken as a single dose, but it can be taken for around 3 days for some infections. The most common side effect is stomach pain.

Who should not take Etos Wormkuurten Mebendazol?

Tell your doctor if you are pregnant or plan to become pregnant. Etos Wormkuurten Mebendazol can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. Etos Wormkuurten Mebendazol is not approved for use by anyone younger than 2 years old.

What happens if I overdose?

Seek emergency medical attention. Overdose symptoms may include upper stomach pain, loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes).

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Can Etos Wormkuurten Mebendazol cause liver damage?

Etos Wormkuurten Mebendazol when given for prolonged periods in high doses has been associated with elevations in serum enzyme levels, and rare instances of acute, clinically apparent liver injury have been linked to its use.

*** Taking medicines without doctor's advice can cause long-term problems.
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