Eucool

Eucool Uses, Dosage, Side Effects, Food Interaction and all others data.

Eucool is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.

Eucool is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Trade Name Eucool
Generic Domperidone
Domperidone Other Names Domperidona, Domperidone, Domperidonum
Type Dsr Capsule
Formula C22H24ClN5O2
Weight Average: 425.911
Monoisotopic: 425.161852744
Protein binding

91%-93%

Groups Approved, Investigational, Vet approved
Therapeutic Class Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
Manufacturer Eugenetic
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Eucool
Eucool

Uses

Stimulation of gut motility in-

  • Non-ulcer dyspepsia
  • Oesophageal reflux, reflux oesophagitis and gastritis
  • Diabetic gastroparesis
  • Functional dyspepsia
  • Speeding barium transit in follow through radiological studies

Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.

In the prophylactic treatment of migraine.

Eucool is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders

How Eucool works

Eucool acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Eucool facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting

Dosage

Eucool dosage

Adults: 10 - 20 mg every 4 - 8 hours daily

Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.

Eucool tablet and suspension should be taken 15 - 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.

Side Effects

Eucool may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.

Toxicity

Side effects include galactorrhea, gynecomastia, or menstrual irregularities.

Precaution

Eucool should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.

Interaction

Eucool may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Eucool on gastrointestinal function.

Food Interaction

  • Take before a meal. Take 15-30 minutes before meals.

Half Life

7 hours

Pregnancy & Breastfeeding use

Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.

Use in lactation: Eucool may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.

Contraindication

Eucool is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.

Acute Overdose

Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.

Storage Condition

Store in a cool dry place protected from light. Keep out of reach of children.

Innovators Monograph

You find simplified version here Eucool

Eucool contains Domperidone see full prescribing information from innovator Eucool Monograph, Eucool MSDS, Eucool FDA label

FAQ

What is Eucool used for?

Eucool help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care. Eucool is sometimes used to increase milk supply.

Is Eucool safe to take?

For most people, taking Eucool is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.

What are the side effects of Eucool?

Common side effects of Eucool are include:

  • swelling of the ankles/feet.
  • unusual tiredness.
  • mental/mood changes (e.g., nervousness, irritability)
  • hot flashes.
  • breast swelling/pain.
  • unusual leakage of milk from the breast.
  • changes in menstrual periods.
  • decreased sexual ability.

Is Eucoolsafe during pregnancy?

Eucool is not usually recommended in pregnancy.

Why Eucool is not safe in pregnancy?

Eucool is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.

Is Eucool safe during breastfeeding?

A very small amount of the Eucool you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Eucool.

Can I drink alcohol with Eucool?

It is best to avoid alcohol when taking Eucool. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.

How long does Eucool take to work?

Eucool often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.

Can I take Eucool before bed?

Eucool is best taken 15 to 30 minutes before meals and id necessary at bedtime.

Is Eucool good for acid reflux?

It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.

Can I take Eucool after eating?

Eucool is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Eucool after a meal, it will still work, but it may take longer to have an effect.

Is Eucool good for gastritis?

Eucool has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Eucool is a kind of drug to strengthen gastric motility.

What does Eucool do to your body?

Eucool is a medicine that increases the movements or contractions of the stomach and bowel. Eucool is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.

Is Eucool safe for kidneys?

Eucool are not significantly renally cleared and can be used in CKD.

Does Eucool help anxiety?

Eucool is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.

Does Eucool raise blood pressure?

Eucool increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.

Is Eucool a narcotic?

Eucool is not a controlled substance e.g. sleeping pills, valium, narcotics.

Does Eucool cause depression?

Eucool can cause central nervous system side effects such as fatigue, irritability, or depression.

Can I take Eucool for a long time?

You should usually take Eucool for up to a week.Because Eucool can cause an irregular heartbeat if you take it for longer or at a high dose.

What happens when I stop taking Eucool?

Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Eucool slowly.

*** Taking medicines without doctor's advice can cause long-term problems.
Share