Eudaxen Tablet 50 mg

Eudaxen Tablet 50 mg Uses, Dosage, Side Effects, Food Interaction and all others data.

A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.

Eudaxen Tablet 50 mg is a potassium channel activator. Its mechanism of action revolves around enhancing cell membrane permeability to potassium ions. This action consequently elicits the relaxation of local smooth muscles. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

Trade Name Eudaxen Tablet 50 mg
Availability Prescription only
Generic Diazoxide
Diazoxide Other Names Diazossido, Diazoxide, Diazoxido, Diazoxidum
Related Drugs hydralazine, nifedipine, captopril, enalapril, labetalol, glucagon, methyldopa, Baqsimi, Gvoke, GlucaGen
Weight 50 mg
Type Tablet
Formula C8H7ClN2O2S
Weight Average: 230.671
Monoisotopic: 229.991675875
Protein binding

Very high (more than 90%) to serum proteins.

Groups Approved
Therapeutic Class
Manufacturer Everest Pharmaceuticals Ltd.
Available Country Bangladesh
Last Updated: October 19, 2023 at 6:27 am
Eudaxen Tablet 50 mg
Eudaxen Tablet 50 mg

Uses

Eudaxen Tablet 50 mg is a non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions.

Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.

Eudaxen Tablet 50 mg is also used to associated treatment for these conditions: Hyperinsulinemic Hypoglycemia

How Eudaxen Tablet 50 mg works

Eudaxen Tablet 50 mg inhibits insulin release from the pancreas, by opening potassium channels in the beta cell membrane. Eudaxen Tablet 50 mg is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. It also exhibits hypotensive activity by reducing arteriolar smooth muscle and vascular resistance.

Toxicity

Oral LD50 in rat and mouse: 980 mg/kg and 444 mg/kg, respectively.

Food Interaction

No interactions found.

Elimination Route

Readily absorbed following oral administration.

Half Life

28 ±8.3 hours in normal adults.

Elimination Route

Proglycem is extensively bound (more than 90%) to serum proteins, and is excreted in the kidneys.

Innovators Monograph

You find simplified version here Eudaxen Tablet 50 mg

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