Expo Extinosad

Expo Extinosad Uses, Dosage, Side Effects, Food Interaction and all others data.

Expo Extinosad is a pediculicide mixture of spinosyn A and spinosyn D (in an approximately 5:1 ratio, respectively) used in the topical treatment of head lice in children (four years old and older) and in adults. Expo Extinosad is an insecticide based on a compound found in S. spinosa, a bacterial species. Expo Extinosad has also been experimented for use in cats for treatment of flea infestations, and has also been experimented for use against the KS1 Ctenocephalides felis flea strain infesting dogs, in addition to many investigations for use in other animals and agricultural plants.

Spinosyn A does not appear to directly interact with any known relevant insecticidal targets, but instead boasts a novel mechanism that resembles a GABA antagonist. Spinosyn A is also slightly more biologically active than spinosyn D.

Trade Name Expo Extinosad
Availability Prescription only
Generic Spinosad
Spinosad Other Names Spinosad
Related Drugs ivermectin topical, sodium chloride topical, permethrin topical, Elimite, acetic acid topical, Natroba, Nix Cream Rinse, Lice Treatment, RID
Type
Formula C83H132N2O20
Weight Average: 1477.963
Monoisotopic: 1476.937344658
Protein binding

Not plasma protein bound if administered topically.

Groups Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country New Zealand
Last Updated: September 19, 2023 at 7:00 am
Expo Extinosad
Expo Extinosad

Uses

Expo Extinosad is a pediculicide used topically to treat head lice.

Expo Extinosad is indicated for the topical treatment of head lice in children four years old and over and in adults.

Expo Extinosad is also used to associated treatment for these conditions: Head Lice Infestation

How Expo Extinosad works

Expo Extinosad is a mixture of spinosyn A and spinosyn D in a 5:1 ratio. This combination causes neuronal hyperexcitation through mostly alteration of nicotinic acetylcholine receptors, which ultimately leads to lice paralysis and death.

Toxicity

Natroba contains benzyl alcohol, which should be avoided in neonates due to associated severe adverse effects and potential fatality. For use only on the scalp and associated hair. Avoid ingestion and contact with eyes. Expo Extinosad itself is not hazardous by the oral, dermal, ocular, or inhalational routes.

Food Interaction

  • Take with or without food.

Expo Extinosad Disease Interaction

Major: prematurity

Volume of Distribution

No distribution if administered topically.

Elimination Route

Not absorbed if administered topically.

Innovators Monograph

You find simplified version here Expo Extinosad

*** Taking medicines without doctor's advice can cause long-term problems.
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