Fegus Vaginal

Fegus Vaginal Uses, Dosage, Side Effects, Food Interaction and all others data.

Fegus Vaginal is a potent broad-spectrum antimycotic agent. It exerts fungistatic and fungicidal actions on dermatophytes, pathogenic yeasts, dimorphous fungi and molds. In addition, Fegus Vaginal is active against gram-positive bacteria and is therefore indicated in mycoses associated with bacterial super infections.

Fegus Vaginal is also active, both in vitro and in vivo, against Trichomonas vaginalis.

Fegus Vaginal exerts its unique antimycotic action through following three ways:

Inhibiting the biosynthesis of ergosterol leading to the damage of fungal cell membrane.Causing certain changes in oxidative and peroxidative enzyme activities inside fungal cell. This leads to an intracellular build-up of toxic concentrations of hydrogen peroxide resulting in cell necrosis.Inhibiting the secretion of aspartic proteases (responsible for pathogenicity) by Candidaalbicans.The amount of Fegus Vaginal absorbed by the transcutaneous route is negligible.

Inhibitingthebiosynthesisofergosterolleadingtothedamageoffungalcellmembrane.Causingcertainchangesinoxidativeandperoxidativeenzymeactivitiesinsidefungalcell.Thisleadstoanintracellularbuild-upoftoxicconcentrationsofhydrogenperoxideresultingincellnecrosis.Inhibitingthesecretionofasparticproteases(responsibleforpathogenicity)byCandidaalbicans.TheamountofFegus Vaginalabsorbedbythetranscutaneousrouteisnegligible.

Fegus Vaginal
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Fegus Vaginal
Generic	Fenticonazole
Fenticonazole Other Names	Fenticonazole
Type	Capsule
Formula	C₂₄H₂₀Cl₂N₂OS
Weight	Average: 455.4 Monoisotopic: 454.0673398
Groups	Experimental
Therapeutic Class	Topical Antifungal preparations
Manufacturer	Koye Pharmaceuticals Pvt Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Fegus Vaginal Nitrate is used for:

Genital candidiasis (vulvovaginitis, colpitis, infectious fuor)
Trichomonasis
Vaginal infections sustained by mixed forms of Trichomonas vaginalis and Candida albicans.

Fegus Vaginal is also used to associated treatment for these conditions: Balanitis, Balanoposthitis, Candidiasis of skin NOS, Dermatomycoses, Erythrasma, Genital candidiasis, Infection caused by Malassezia infection of the scalp, Mycoses, Nail infection, Onycholysis, Otomycosis, Pityriasis versicolor, Tinea Capitis, Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea Unguium, Tinea barbae, Tinea faciei, Tinea manuum, Trichophytosis, Vaginal Candidiasis

Dosage

Fegus Vaginal dosage

ginal tablet-

Vaginal infections: Fegus Vaginal 600 mg vaginal tablet(followed by a second administration 24 hours later, if necessary).
Candida albicans infections: Fegus Vaginal 600 mg vaginal tablet administration in the evening. Should the symptoms persist, a second administration may be repeated after three days. The vaginal tablet must be introduced deep into the vagina and pushed well up to the fornix. To avoid re-infection, it is recommended that the partner undergoes concurrent treatment with Fegus Vaginal Cream or similar Azole Cream.

Cream

: Apply 2% cream once daily

Side Effects

After intravaginal administration slight transient burning (which usually disappears rapidly) may occasionally happen. Prolonged topical application may cause sensitisation reactions. Fegus Vaginal is generally well tolerated by the mucous membranes; only exceptionally mild and transient erythematous reactions have been reported. After topical application or intravaginal administration, a slight burning sensation may occur, usually subsiding soon. Should more persistent irritation occur or resistant micro-organism develop, suspend the treatment and seek the doctor's advice. Due to poor absorption of Fegus Vaginal, no systemic efects should occur, provided the above instructions are carefully observed.

Precaution

Discontinue if sensitization or irritation occur. Pregnancy and lactation

Pregnancy & Breastfeeding use

It is not recommended in pregnancy. Safety in breastfeeding has not been established.

Contraindication

Contraindicated in case of hypersensitivity to Fegus Vaginal and other Imidazoles.

Special Warning

Fegus Vaginal Nitrate is not recommended for children.

Acute Overdose

As systemic absorption is very low, the possibility of overdose is rare. In case of accidental swallowing, emesis or gastric lavage should be done. After vomiting, active charcoal along with water/lemon juice and laxative should be given to the patient.