Fenoldopam Mesylate Baxter

Fenoldopam Mesylate Baxter Uses, Dosage, Side Effects, Food Interaction and all others data.

A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.

Fenoldopam Mesylate Baxter is an agonist at D1-like dopamine receptors, binds to α2-adrenoceptors, increasing renal blood flow.

Trade Name Fenoldopam Mesylate Baxter
Availability Prescription only
Generic Fenoldopam
Fenoldopam Other Names Fénoldopam, Fenoldopam, Fenoldopamum
Related Drugs hydralazine, nifedipine, captopril, enalapril, labetalol, methyldopa, Corlopam
Type
Formula C16H16ClNO3
Weight Average: 305.756
Monoisotopic: 305.08187109
Groups Approved
Therapeutic Class
Manufacturer
Available Country USA
Last Updated: September 19, 2023 at 7:00 am
Fenoldopam Mesylate Baxter
Fenoldopam Mesylate Baxter

Uses

Fenoldopam Mesylate Baxter is a dopamine D1 receptor agonist used for the short term management of hypertension.

For the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function.

Fenoldopam Mesylate Baxter is also used to associated treatment for these conditions: Malignant Hypertension, Severe Hypertension

How Fenoldopam Mesylate Baxter works

Fenoldopam Mesylate Baxter is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and β-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam Mesylate Baxter is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D1-like receptors than does the S-isomer. In non-clinical studies, fenoldopam had no agonist effect on presynaptic D2-like dopamine receptors, or α or β -adrenoceptors, nor did it affect angiotensin-converting enzyme activity. Fenoldopam Mesylate Baxter may increase norepinephrine plasma concentration.

Toxicity

The most likely reaction of overdose would be excessive hypotension which should be treated with drug discontinuation and appropriate supportive measures.

Food Interaction

  • Take on an empty stomach. Orally administered fenoldopam should be taken in a fasted state for optimal absorption.

Fenoldopam Mesylate Baxter Alcohol interaction

[Moderate]

Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation.

Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.

Caution and close monitoring for development of hypotension is advised during coadministration of these agents.

Some authorities recommend avoiding alcohol in patients receiving vasodilating antihypertensive drugs.

Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.

Fenoldopam Mesylate Baxter Disease Interaction

Major: congestive heart failure, glaucoma, hypokalemia, hypotension, tachycardia

Half Life

The elimination half-life is about 5 minutes in mild to moderate hypertensives, with little difference between the R (active) and S isomers.

Elimination Route

Radiolabeled studies show that about 90% of infused fenoldopam is eliminated in urine, 10% in feces. Elimination is largely by conjugation, without participation of cytochrome P-450 enzymes. Only 4% of the administered dose is excreted unchanged.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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