Fentas Plus

Fentas Plus Uses, Dosage, Side Effects, Food Interaction and all others data.

Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms, pinworms, aelurostrongylus, paragonimiasis, strongyles, and Strongyloides. Fenbendazole is approved to be administered under veterinary to sheep, cattle, horses, fish, dogs, cats, rabbits and seals.

An anthelmintic used in most schistosome and many cestode infestations.

Praziquantel is an anthelmintic used in most schistosome and many cestode infestations. Praziquantel effects the permeability of the cell membrane resulting in the contraction of schistosomes. The drug further causes vacuolization and disintegration of the schistosome tegument. The effect is more marked on adult worms compared to young worms. An increased calcium influx may play an important role. Secondary effects are inhibition of glucose uptake, lowering of glycogen levels and stimulation of lactate release. The action of praziquantel is limited very specifically to trematodes and cestodes; nematodes (including filariae) are not affected.

Trade Name Fentas Plus
Generic Fenbendazole + Praziquantel
Weight 15mg
Type Suspension, Liquid, Bolus, Bottle, Vet
Therapeutic Class
Manufacturer Intas Pharmaceuticals Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Fentas Plus
Fentas Plus

Uses

Praziquantel is an anthelmintic medication used to treat a number of parasitic worm infections such as schistosomiasis.

For the treatment of infections due to all species of schistosoma.

Fentas Plus is also used to associated treatment for these conditions: Cestode infections, Cysticercosis, Liver fluke infection, Trematode infections, Schistosoma infection

How Fentas Plus works

Praziquantel works by causing severe spasms and paralysis of the worms' muscles. This paralysis is accompanied - and probably caused - by a rapid Ca 2+ influx inside the schistosome. Morphological alterations are another early effect of praziquantel. These morphological alterations are accompanied by an increased exposure of schistosome antigens at the parasite surface. The worms are then either completely destroyed in the intestine or passed in the stool. An interesting quirk of praziquantel is that it is relatively ineffective against juvenile schistosomes. While initially effective, effectiveness against schistosomes decreases until it reaches a minimum at 3-4 weeks. Effectiveness then increases again until it is once again fully effective at 6-7 weeks. Glutathione S-transferase (GST), an essential detoxification enzyme in parasitic helminths, is a major vaccine target and a drug target against schistosomiasis. Schistosome calcium ion channels are currently the only known target of praziquantel.

Elimination Route

Rapidly absorbed (80%)

Half Life

0.8-1.5 hours (in serum)

Innovators Monograph

You find simplified version here Fentas Plus


*** Taking medicines without doctor's advice can cause long-term problems.
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