Fenticad
Fenticad Uses, Dosage, Side Effects, Food Interaction and all others data.
Fenticad is a potent broad-spectrum antimycotic agent. It exerts fungistatic and fungicidal actions on dermatophytes, pathogenic yeasts, dimorphous fungi and molds. In addition, Fenticad is active against gram-positive bacteria and is therefore indicated in mycoses associated with bacterial super infections.
Fenticad is also active, both in vitro and in vivo, against Trichomonas vaginalis.
Fenticad exerts its unique antimycotic action through following three ways:
Inhibiting the biosynthesis of ergosterol leading to the damage of fungal cell membrane.Causing certain changes in oxidative and peroxidative enzyme activities inside fungal cell. This leads to an intracellular build-up of toxic concentrations of hydrogen peroxide resulting in cell necrosis.Inhibiting the secretion of aspartic proteases (responsible for pathogenicity) by Candidaalbicans.The amount of Fenticad absorbed by the transcutaneous route is negligible.
Inhibitingthebiosynthesisofergosterolleadingtothedamageoffungalcellmembrane.Causingcertainchangesinoxidativeandperoxidativeenzymeactivitiesinsidefungalcell.Thisleadstoanintracellularbuild-upoftoxicconcentrationsofhydrogenperoxideresultingincellnecrosis.Inhibitingthesecretionofasparticproteases(responsibleforpathogenicity)byCandidaalbicans.TheamountofFenticadabsorbedbythetranscutaneousrouteisnegligible.
Trade Name | Fenticad |
Generic | Fenticonazole |
Fenticonazole Other Names | Fenticonazole |
Type | Vaginal Capsule |
Formula | C24H20Cl2N2OS |
Weight | Average: 455.4 Monoisotopic: 454.0673398 |
Groups | Experimental |
Therapeutic Class | Topical Antifungal preparations |
Manufacturer | Cadila Pharmaceuticals Limited |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Fenticad Nitrate is used for:
- Genital candidiasis (vulvovaginitis, colpitis, infectious fuor)
- Trichomonasis
- Vaginal infections sustained by mixed forms of Trichomonas vaginalis and Candida albicans.
Fenticad is also used to associated treatment for these conditions: Balanitis, Balanoposthitis, Candidiasis of skin NOS, Dermatomycoses, Erythrasma, Genital candidiasis, Infection caused by Malassezia infection of the scalp, Mycoses, Nail infection, Onycholysis, Otomycosis, Pityriasis versicolor, Tinea Capitis, Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea Unguium, Tinea barbae, Tinea faciei, Tinea manuum, Trichophytosis, Vaginal Candidiasis
Dosage
Fenticad dosage
ginal tablet-
- Vaginal infections: Fenticad 600 mg vaginal tablet(followed by a second administration 24 hours later, if necessary).
- Candida albicans infections: Fenticad 600 mg vaginal tablet administration in the evening. Should the symptoms persist, a second administration may be repeated after three days. The vaginal tablet must be introduced deep into the vagina and pushed well up to the fornix. To avoid re-infection, it is recommended that the partner undergoes concurrent treatment with Fenticad Cream or similar Azole Cream.
Cream
- : Apply 2% cream once daily
Side Effects
After intravaginal administration slight transient burning (which usually disappears rapidly) may occasionally happen. Prolonged topical application may cause sensitisation reactions. Fenticad is generally well tolerated by the mucous membranes; only exceptionally mild and transient erythematous reactions have been reported. After topical application or intravaginal administration, a slight burning sensation may occur, usually subsiding soon. Should more persistent irritation occur or resistant micro-organism develop, suspend the treatment and seek the doctor's advice. Due to poor absorption of Fenticad, no systemic efects should occur, provided the above instructions are carefully observed.
Precaution
Discontinue if sensitization or irritation occur. Pregnancy and lactation
Pregnancy & Breastfeeding use
It is not recommended in pregnancy. Safety in breastfeeding has not been established.
Contraindication
Contraindicated in case of hypersensitivity to Fenticad and other Imidazoles.
Special Warning
Fenticad Nitrate is not recommended for children.
Acute Overdose
As systemic absorption is very low, the possibility of overdose is rare. In case of accidental swallowing, emesis or gastric lavage should be done. After vomiting, active charcoal along with water/lemon juice and laxative should be given to the patient.
Storage Condition
Store below 25°C. Protect from light & moisture.
Innovators Monograph
You find simplified version here Fenticad