Feromine
Feromine Uses, Dosage, Side Effects, Food Interaction and all others data.
An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator. [PubChem]
Feromine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Feromine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Feromine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Feromine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.
| Trade Name | Feromine |
| Availability | Prescription only |
| Generic | Phenoxybenzamine |
| Phenoxybenzamine Other Names | Fenossibenzamina, Fenoxibenzamina, Phenoxybenzamine, Phenoxybenzaminum |
| Related Drugs | propranolol, labetalol, Inderal, phentolamine, Normodyne, Trandate |
| Type | |
| Formula | C18H22ClNO |
| Weight | Average: 303.826 Monoisotopic: 303.138992038 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Taiwan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Feromine is an alpha adrenergic agonist used to treat pheochromocytoma and episodes of hypertension and sweating.
For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension.
Feromine is also used to associated treatment for these conditions: Micturition Disorder, Pheochromocytomas, Urinary Retention
How Feromine works
Feromine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure.
Toxicity
Symptoms of overdose are largely the result of block of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension resulting in dizziness or fainting, tachycardia, particularly postural, vomiting; lethargy, and shock.
Food Interaction
No interactions found.Feromine Drug Interaction
Moderate: hydroxyzine, clonidineUnknown: amphetamine / dextroamphetamine, fluticasone / salmeterol, sulfamethoxazole / trimethoprim, celecoxib, varenicline, ciprofloxacin, glatiramer, warfarin, duloxetine, sacubitril / valsartan, furosemide, pregabalin, gabapentin, esomeprazole, amlodipine, valacyclovir, ondansetron, cetirizine
Feromine Disease Interaction
Major: cardiovascular dysfunctionModerate: renal damage, respiratory infections
Elimination Route
Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active form.
Half Life
24 hours
Innovators Monograph
You find simplified version here Feromine
