Fildesin

Fildesin Uses, Dosage, Side Effects, Food Interaction and all others data.

Vinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Fildesin is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols).

Fildesin is indicated for the treatment of acute lymphocytic leukemia of childhood that is resistant to vincristine and non-oat cell lung cancer. Fildesin causes the arrest of cells in metaphase mitosis. It is three times more potent than vincristine and nearly 10 times more potent than vinblastine in causing mitotic arrest in in vitro studies at doses designed to arrest from 10 to 15% of the cells in mitosis. Fildesin and vincristine are approximately equipotent at dose levels that arrest 40 to 50% of the cells in mitosis. Unlike vinblastine, vindesine produces very few postmetaphase cells. Fildesin has demonstrated activity in patients who have relapsed while receiving multiple-agent treatment that included vincristine.

Table Of contents

• Fildesin
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Fildesin
Generic	Vindesine
Vindesine Other Names	Desacetylvinblastine amide, Vindesina, Vindesine, Vindesinum
Type
Formula	C43H55N5O7
Weight	Average: 753.941 Monoisotopic: 753.410149131
Protein binding	65-75%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	Japan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Fildesin is a vinca alkaloid derived from vinblastine used for various types of malignancies, but mainly acute lymphocytic leukemia (ALL).

For the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis

Fildesin is also used to associated treatment for these conditions: Acute Lymphocytic Leukemia (ALL), Blast Crisis, Melanoma, Malignant

How Fildesin works

Fildesin acts by causing the arrest of cells in metaphase mitosis through its inhibition tubulin mitotic funcitoning. The drug is cell-cycle specific for the S phase.

Food Interaction

• Exercise caution with grapefruit products. Fildesin is metabolized by CYP3A4, and grapefruit inhibits CYP3A4 metabolism, which may increase vindesine serum levels.
• Exercise caution with St. John's Wort. Fildesin is metabolized by CYP3A4 and this herb induces CYP3A4 metabolism, which may reduce vindesine serum levels.

Half Life

24 hours.

Innovators Monograph

You find simplified version here Fildesin