Flintrocin

Flintrocin Uses, Dosage, Side Effects, Food Interaction and all others data.

Flintrocin Hydrochloride is a phenylpropylamine derivative antidepressant for oral administration, it is chemically unrelated to tricyclic, tetracycline or other available antidepressants.

Flintrocin has been shown to selectively inhibit the reuptake of serotonin (5-HT) at the presynaptic neuronal membrane which causes increased synaptic concentration of serotonin in the CNS. This results in numerous functional changes associated with enhanced serotonergic neurotransmission.

Flintrocin appears to have no effect on the reuptake of norepinephrine and dopamine and does not exhibit antihistaminic or alpha1 adrenergic blocking activity at usual therapeutic doses.

Flintrocin blocks the serotonin reuptake transporter in the presynaptic terminal, which ultimately results in sustained levels of 5-hydroxytryptamine (5-HT) in certain brain areas. However, fluoxetine binds with relatively poor affinity to 5-HT, dopaminergic, adrenergic, cholinergic, muscarinic, and histamine receptors which explains why it has a far more desirable adverse effect profile compared to earlier developed classes of antidepressants such as tricyclic antidepressants.

Trade Name Flintrocin
Availability Prescription only
Generic Fluoxetine
Fluoxetine Other Names Fluoxetin, Fluoxetina, Fluoxétine, Fluoxetine, Fluoxetinum
Related Drugs Rexulti, sertraline, trazodone, alprazolam, clonazepam, Lexapro, amitriptyline, venlafaxine, Zoloft, citalopram
Weight 20mg/5ml
Type Syrup
Formula C17H18F3NO
Weight Average: 309.3261
Monoisotopic: 309.134048818
Protein binding

Approximately 94% of fluoxetine is plasma protein bound.

Groups Approved, Vet approved
Therapeutic Class Phenothiazine related drugs
Manufacturer Life Pharmaceutical Company
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Flintrocin
Flintrocin

Uses

Flintrocin is used for-

  • Depressive illness
  • Bulimia nervosa and anorexia nervosa
  • Obsessive compulsive disorders
  • Pre-menstrual syndrome

Flintrocin is also used to associated treatment for these conditions: Alcohol Dependency, Anorexia Nervosa (AN), BMI >30 kg/m2, Bulimia Nervosa, Cataplexy, Depression, Bipolar, Major Depressive Disorder (MDD), Myoclonus, Obsessive Compulsive Disorder (OCD), Panic Disorder (With or Without Agoraphobia), Premature Ejaculation, Premenstrual Dysphoric Disorder, Treatment Resistant Depression (TRD)

How Flintrocin works

The monoaminergic hypothesis of depression emerged in 1965 and linked depression with dysfunction of neurotransmitters such as noradrenaline and serotonin. Indeed, low levels of serotonin have been observed in the cerebrospinal fluid of patients diagnosed with depression. As a result of this hypothesis, drugs that modulate levels of serotonin such as fluoxetine were developed.

Flintrocin is a selective serotonin reuptake inhibitor (SSRI) and as the name suggests, it exerts it's therapeutic effect by inhibiting the presynaptic reuptake of the neurotransmitter serotonin. As a result, levels of 5-hydroxytryptamine (5-HT) are increased in various parts of the brain. Further, fluoxetine has high affinity for 5-HT transporters, weak affinity for noradrenaline transporters and no affinity for dopamine transporters indicating that it is 5-HT selective.

Flintrocin interacts to a degree with the 5-HT2C receptor and it has been suggested that through this mechanism, it is able to increase noradrenaline and dopamine levels in the prefrontal cortex.

Dosage

Flintrocin dosage

Initial treatment: Recent studies suggest that 20 mg/day of Flintrocin may be sufficient to obtain satisfactory antidepressant response. Consequently, a dose of 20 mg/day administered in the morning is recommended as the initial dose.

A dose increase may be considered after several weeks if no clinical improvement is observed. Dosage above 20 mg/day, should be administered on a bid schedule (i.e. morning and noon) and should not exceed a maximum dose of 80 mg/day. As with other antidepressants, the full antidepressant effect may be delayed until 4 weeks of treatment or longer. As with many other medications, a lower or less frequent dosage should be used in patients with renal and/or hepatic impairment.

A lower or less frequent dosage should also be considered for patients, such as elderly, with concurrent disease or on multiple medication. A recommended maximum dose for elderly patients is 60 mg per day.

Maintenance treatment: It is generally agreed among expert psychopharmacologists that acute episode of depression requires several months or longer sustained pharmacologic therapy. Flintrocin is also used in dosage of 60 mg daily for the management of bulimia nervosa.

Side Effects

Gastrointestinal: Nausea, vomiting, dyspepsia, dry mouth, and diarrhoea.

Neurological: Anxiety, nervousness, insomnia/ drowsiness and fatigue.

Others: Excessive sweating, pruritus, skin rashes associated with liver, kidney and lung involvement. It has therefore been advised that Flintrocin therapy should be discontinued in any patient who develops a skin rash.

Toxicity

In a report that included 234 fluoxetine overdose cases, it was concluded that symptoms resulting from fluoxetine overdose were generally minor and short in duration. The most common overdose adverse effects included drowsiness, tremor, tachycardia, nausea and vomiting, and providing the patient with aggressive supportive care was the recommended intervention.

Despite this evidence, more severe adverse effects have been linked to fluoxetine ingestion although most of these reports involved co-ingestion with other substances or drugs as well as other factors. For example, there is a case report that details a patient who ingested 1400 mg of fluoxetine in a suicide attempt and as a result, experienced a generalized seizure three hours later. In a separate case, a 14 year old patient ingested 1.2 g of fluoxetine and subsequently experienced tonic/clonic seizures, symptoms consistent with serotonin syndrome, and rhabdomyolysis, although the patient did not experience sustained renal injury.

Precaution

As Flintrocin undergoes hepatic metabolism and renal excretion, it should be used with caution and in reduced doses in patients with impaired hepatic or renal function. Because of its epileptogenic effect, it should be used with caution in patients with epilepsy or a history of such disorders. Flintrocin may alter glycaemic control and therefore caution is also warranted in diabetic subjects. Depressed patients with suicidal tendencies should be carefully supervised during treatment. Flintrocin is not usually considered a suitable form of therapy for the depressive component of bipolar (manic depressive) illness as mania may be precipitated.

Interaction

May lead to serotonin syndrome with serotonergic drugs (e.g. triptans, TCAs, fentanyl, tramadol, lithium, buspirone, tryptophan). May increase risk of bleeding with aspirin, NSAIDs, warfarin and other anticoagulants. May increase plasma levels of phenytoin.

Potentially Fatal: May increase risk of serotonin syndrome with concomitant admin or within 14 days of MAOIs withdrawal. May increase the QTc prolonging effect of pimozide and thioridazine.

Food Interaction

  • Avoid alcohol.
  • Take with or without food.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Volume of Distribution

The volume of distribution of fluoxetine and it's metabolite varies between 20 to 42 L/kg.

Elimination Route

The oral bioavailability of fluoxetine is 13

In a bioequivalence study, the Cmax of fluoxetine 20 mg for the established reference formulation was 11.754 ng/mL while the Cmax for the proposed generic formulation was 11.786 ng/ml.

Flintrocin is very lipophilic and highly plasma protein bound, allowing the drug and it's active metabolite, norfluoxetine, to be distributed to the brain.

Half Life

The half life of fluoxetine is significant with the elimination half-life of the parent drug averaging 1-3 days after acute administration, and 4-6 days after chronic administration. Further, the elimination half life of it's active metabolite, norfluoxetine, ranges from 4-16 days after both acute and chronic administration. The half-life of fluoxetine should be considered when switching patients from fluoxetine to another antidepressant since marked accumulation occurs after chronic use. Flintrocin's long half-life may even be beneficial when discontinuing the drug since the risk of withdrawal is minimized.

Clearance

The clearance value of fluoxetine in healthy patients is reported to be 9.6 ml/min/kg.

Elimination Route

Flintrocin is primarily eliminated in the urine.

Pregnancy & Breastfeeding use

Pregnancy: In animal studies, no teratogenicity or harmful effect was found. Because animal reproductive studies are not always predictive of human responses, Flintrocin should be used in pregnancy only if clearly needed.

Lactation: As Flintrocin is excreted in human milk, caution should be exercised when Flintrocin is administered to nursing women.

Contraindication

Flintrocin Hydrochloride is contraindicated in patients known to be hypersensitive to it.

Monoamine oxidase inhibitors: There have been reports of serious, sometimes fatal reactions (including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs and changes of mental status that include extreme agitation progressing to delirium and coma) in patients receiving Flintrocin in combination with monoamine oxidase inhibitors (MAOIs), and in patients who have recently discontinued Flintrocin and are then started on MAOIs. Some cases presented with features resembling neuroleptic malignant syndrome. Therefore, Flintrocin should not be used in combination with MAOI, or within 14 days of discontinuing therapy with MAOI. Since Flintrocin and its major metabolites have very long elimination half-lives, at least 5 weeks should be allowed after stopping Flintrocin and before starting MAOI.

Special Warning

Use in children: The use of Flintrocin in children is not recommended as safety and efficacy have not been established.

Acute Overdose

Symptoms: Nausea, vomiting, seizure, CV dysfunction ranging from asymptomatic arrhythmias to cardiac arrest (including ventricular arrhythmias and nodal rhythm) or ECG changes indicative of QTc prolongation to cardiac arrest, pulmonary dysfunction, signs of altered CNS status ranging from excitation to coma.

Management: Symptomatic and supportive treatment. May admin activated charcoal w/ sorbitol.

Storage Condition

Store between 20-25° C. Protect from light.

Innovators Monograph

You find simplified version here Flintrocin

Flintrocin contains Fluoxetine see full prescribing information from innovator Flintrocin Monograph, Flintrocin MSDS, Flintrocin FDA label

FAQ

What is Flintrocin used for?

Flintrocin is a type of antidepressant known as an SSRI (selective serotonin reuptake inhibitor). It is often used to treat depression, and also sometimes obsessive compulsive disorder and bulimia. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. brans also often prescribe Prozac to treat other types of anxiety as well.

How safe is Flintrocin?

It is considered safe and effective in treating depression, anxiety, and obsessive compulsive disorder, and bulimia. Adverse effects include an increased risk of suicidal thoughts in some younger people.

How does Flintrocin work?

Flintrocin works by blocking the absorption of the neurotransmitter serotonin in the brain.

What are the common side effects of Flintrocin?

Common side effects of Flintrocin are include:

  • nervousness
  • anxiety
  • difficulty falling asleep or staying asleep
  • nausea
  • diarrhea
  • dry mouth
  • heartburn
  • yawning
  • weakness
  • uncontrollable shaking of a part of the body
  • loss of appetite
  • weight loss
  • changes in sex drive or ability
  • excessive sweating
  • headache, confusion, weakness, difficulty concentrating, or memory problems

Is Flintrocin safe during pregnancy?

Flintrocin is one of the safest antidepressants you can take during pregnancy .

Is Flintrocin safe during breastfeeding?

A safety scoring system finds Flintrocin use to be possible during breastfeeding, although others do not recommend its use. If the mother was taking Flintrocin during pregnancy or if other antidepressants have been ineffective, most experts recommend against changing medications during breastfeeding.

Can I drink alcohol with Flintrocin?

Alcohol can increase the nervous system side effects of Flintrocin such as dizziness, drowsiness, and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with Flintrocin.

Can I drive after taking Flintrocin?

Flintrocin might be best to stop driving and cycling for the first few days of treatment until you know how this medicine makes you feel.

When should be taken of Flintrocin?

Flintrocin comes as a capsule to take by mouth. Flintrocin capsules, tablets, and liquid are usually taken once a day in the morning or twice a day in the morning and at noon. Flintrocin delayed-released capsules are usually taken once a week.

Can I take Flintrocin on an empty stomach?

Take Flintrocin once a day. You can take it with or without food. You can take Flintrocin at any time, as long as you stick to the same time every day. If you have trouble sleeping, it's best to take it in the morning.

How long does Flintrocin take to work?

It usually takes 4 to 6 weeks for Flintrocin to work.

How long does Flintrocin stay in my system?

Flintrocin stays in the body for 25 days after you stop taking it. Even then, the prescription is only 99 percent out of your system.

Can I take Flintrocin for a long time?

Flintrocin is safe to take for a long time. A few people may get sexual side effects, such as problems getting an erection or a lower sex drive. In some cases these can continue even after stopping the medicine. Speak to your doctor if you are worried.

Who should not take Flintrocin ?

You should not use Flintrocin if you are allergic to Flintrocin, if you also take Flintrocin. Do not use Flintrocin if you have used an MAO inhibitor in the past 14 days.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.If you miss a dose of Flintrocin Weekly, take the missed dose as soon as you remember and take the next dose 7 days later. However, if it is almost time for the next regularly scheduled weekly dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention.

Is Flintrocin safe for heart patients?

Flintrocin are considered lower risk antidepressants with minimal effects on the cardiovascular system.

When is Flintrocin contraindicated?

Flintrocin is contraindicated in those patients with Flintrocin hypersensitivity or hypersensitivity to any of the formulation components. Avoid abrupt discontinuation of any SSRI if possible.

Does Flintrocin make me sleep?

Flintrocin taken for depression or anxiety, can make you feel sleepy.

Can Flintrocin cause weight gain?

Flintrocin make gaining weight more likely.

Does Flintrocin cause hair loss?

Flintrocin can cause hair loss in a very small minority of patients.

Do Flintrocin damage my brain?

Flintrocin seem to cause permanent brain damage.

Can Flintrocin affect my fertility?

No, there isn't any data to suggest that anti-depressants affect female fertility.

Can Flintrocin affect my heart?

Flintrocin induced a statistically significant 6% decrease in heart rate, a 2% increase in supine systolic pressure, and a 7% increase in ejection fraction.

Is Flintrocin bad for my liver?

Flintrocin therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0004551
http://classyfire.wishartlab.com/tax_nodes/C0004551
http://classyfire.wishartlab.com/tax_nodes/C0004742
http://classyfire.wishartlab.com/tax_nodes/C0002341
http://classyfire.wishartlab.com/tax_nodes/C0003899
http://classyfire.wishartlab.com/tax_nodes/C0000128
http://classyfire.wishartlab.com/tax_nodes/C0002228
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0001517
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001027
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:86990
http://www.hmdb.ca/metabolites/HMDB0014615
http://www.genome.jp/dbget-bin/www_bget?drug:D00823
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3386
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507902
https://www.chemspider.com/Chemical-Structure.3269.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30130
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=4493
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=86990
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL41
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000186
http://www.pharmgkb.org/drug/PA449673
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=203
http://www.rxlist.com/cgi/generic/fluoxetine.htm
https://www.drugs.com/fluoxetine.html
https://en.wikipedia.org/wiki/Fluoxetine
*** Taking medicines without doctor's advice can cause long-term problems.
Share