Florobex Ophthalmic Suspension 0.6%
Florobex Ophthalmic Suspension 0.6% Uses, Dosage, Side Effects, Food Interaction and all others data.
Florobex Ophthalmic Suspension 0.6% is an 8-chloro fluoroquinolone anti -infective for topical ophthalmic use. It has activity against both Gram-positive and Gram-negative bacteria due to the inhibition of both bacterial DNA Gyrase and Topoisomerase IV.
Florobex Ophthalmic Suspension 0.6% tear concentrations were higher than MIC90 (minimum inhibitory concentration) values for common bacterial pathogens and sustained for 24 hours or longer. Mean residence time in the conjunctiva was 4.7 hours.
Trade Name | Florobex Ophthalmic Suspension 0.6% |
Generic | Besifloxacin |
Besifloxacin Other Names | Besifloxacin |
Weight | 0.6% |
Type | Ophthalmic Suspension |
Formula | C19H21ClFN3O3 |
Weight | Average: 393.84 Monoisotopic: 393.125547465 |
Protein binding | None |
Groups | Approved |
Therapeutic Class | Ophthalmic antibacterial drugs |
Manufacturer | Ibn Sina Pharmaceuticals Ltd. |
Available Country | Bangladesh |
Last Updated: | October 19, 2023 at 6:27 am |
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Uses
This drug is used for the treatment of bacterial conjunctivitis caused by susceptible isolates of the following bacteria:
CDC coryneform group G, Corynebacterium pseudodiphtheriticum, Corynebacterium striatum, Haemophilus influenza, Moraxella lacunata, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus lugdunensis, Streptococcus mitis group, Streptococcus oralis, Streptococcus pneumonia, Streptococcus salivarius.
Florobex Ophthalmic Suspension 0.6% is also used to associated treatment for these conditions: Bacterial Conjunctivitis
How Florobex Ophthalmic Suspension 0.6% works
Florobex Ophthalmic Suspension 0.6% is a bactericidal fluroquinolone-type antibiotic that inhibits bacterial enzymes, DNA gyrase and topoisomerase IV. By inhibiting DNA gyrase, DNA replication, transcription, and repair is impaired. By inhibiting topoisomerase IV, decatenation during cell devision is impaired. Inhibiting these two targets also slows down development of resistance.
Dosage
Florobex Ophthalmic Suspension 0.6% dosage
Adults and children (1 year of age and older): Instill one drop in the affected eye(s) 3 times a day for 7 days.
Pediatric Use: The safety and effectiveness of Florobex Ophthalmic Suspension 0.6% in infants below one year of age have not been established.
The safety and effectiveness of Florobex Ophthalmic Suspension 0.6% in infants below one year of age have not been established.
Side Effects
The most frequently reported ocular adverse event was conjunctival redness, reported in approximately 2% of patients. Other adverse events reported in approximately 1-2% of patients included: blurred vision, eye pain, eye irritation, eye pruritus and headache.
Toxicity
LD50, rat: >2000 mg/kg. The most common adverse reaction reported in 2% of patients treated with besifloxacin was conjunctival redness.
Precaution
This drug is for topical ophthalmic use only and should not be injected subconjunctivally, nor should it be introduced directly into the anterior chamber of the eye. As with other anti -infectives, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy. To prevent contamination do not touch the tip of the dropper to eye, eyelid or any surface of the affected eye. Patients should not wear contact lenses during the course of therapy with this drug.Shake well before use.
Interaction
No such information found. Topical ophthalmic use only
Food Interaction
No interactions found.Volume of Distribution
Not absorbed into the systemic
Elimination Route
Although ocular surface concentrations are high, average systemic concentrtions after three-times daily dosing was less than 0.5 ng/mL. This indicates that besifloxacin is not appreciably absorbed into the systemic and has a very low risk of systemic side effects.
Half Life
The average elimination half-life of besifloxacin in plasma following multiple dosing was estimated to be 7 hours.
Clearance
N/A
Elimination Route
N/A
Pregnancy & Breastfeeding use
Pregnancy Category C. No adequate and women. This drug should be used during potential risk to the fetus. well-controlled studies are established in pregnant pregnancy only if the potential benefit justifies the It is not known whether Florobex Ophthalmic Suspension 0.6% is secreted in human milk or not. Caution should be exercised when Florobex Ophthalmic Suspension 0.6% is administered to a nursing mother.
Contraindication
Hypersensitivity to the active ingredient or any component of this formulation.
Acute Overdose
No information is available.
Interaction with other Medicine
No information is available.
Storage Condition
Store in a cool, dry place and protected from light. Keep out of the reach of children. Discard the container 4 weeks after opening.
Innovators Monograph
You find simplified version here Florobex Ophthalmic Suspension 0.6%
Florobex Ophthalmic Suspension 0.6% contains Besifloxacin see full prescribing information from innovator Florobex Ophthalmic Suspension 0.6% Monograph, Florobex Ophthalmic Suspension 0.6% MSDS, Florobex Ophthalmic Suspension 0.6% FDA label