Flosted
Flosted Uses, Dosage, Side Effects, Food Interaction and all others data.
Flosted is a corticosteroid with an excellent anti-inflammatory action with no significant influence on the intraocular pressure. The anti-inflammatory activity of Flosted is at least 40 times stronger than that of Hydrocortisone. Corticosteroids are thought to act by the introduction of phospholipase A2 inhibitory proteins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandin and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. In comparison with other corticosteroids Flosted is more rapidly degraded in tissue and therefore has less effect on the intraocular pressure. The immunosuppressive action of Flosted is less pronounced than that of Dexamethasone.
Corticosteroids such as fluorometholone inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.
| Trade Name | Flosted |
| Availability | Prescription only |
| Generic | Fluorometholone |
| Fluorometholone Other Names | Fluorometholon, Fluorométholone, Fluorometholone, Fluorometholonum, Fluorometolona |
| Related Drugs | phenylephrine ophthalmic, brimonidine ophthalmic, oxymetazoline ophthalmic, bimatoprost topical, triprolidine, Latisse, naphazoline ophthalmic, tetrahydrozoline ophthalmic, Naphcon-A |
| Type | Eye Drops |
| Formula | C22H29FO4 |
| Weight | Average: 376.4617 Monoisotopic: 376.204987621 |
| Groups | Approved, Investigational |
| Therapeutic Class | Ophthalmic Steroid preparations |
| Manufacturer | Renova Lifesciences Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Flosted Acetate ophthalmic suspension is used for the treatment of-
- Acute and chronic non-infectious conjunctivitis and keratitis of allergic origin.
- Non-infectious inflammation of the anterior chamber of the eye (including anterior uveitis, episcleritis and scleritis).
- Post-operative irritative conditions after strabismus, cataract and glaucoma surgery.
Flosted is also used to associated treatment for these conditions: Anterior chamber inflammation, Conjunctivitis allergic, Corneal Inflammation, Inflammation, Ocular Inflammation, Ocular bacterial infections
How Flosted works
There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Their primary target is the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.
Dosage
Flosted dosage
1 drop instilled into the conjunctival sac 2-4 times daily. During the initial 24 to 48 hours the dosage may be safely increased to 1 drop every hour. Care should be taken not to discontinue therapy prematurely. Shake well before use.
Side Effects
Glaucoma with optic nerve damage, visual acuity or field defects, cataract formation, secondary ocular infection following suppression of host immunity, perforation of the globe.
Toxicity
Side effects may include acute anterior uveitis and perforation of the globe. Keratitis, conjunctivitis, corneal ulcers, mydriasis, conjunctival hyperemia, loss of accommodation and ptosis have occasionally been reported following local use of corticosteroids. LD50 = 234 mg/kg (rats)
Precaution
Shake well before using. If this product is used for 10 days or longer, intraocular pressure should be monitored.
Interaction
Specific drug interaction studies have not been conducted with Flosted ophthalmic suspension.
Food Interaction
No interactions found.Flosted Disease Interaction
Pregnancy & Breastfeeding use
Safety of the use of topical steroids during pregnancy and lactation has not been established. Flosted ophthalmic suspension should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Contraindication
- Hypersensitivity to any ingredient of the formulation.
- Infectious conjunctivitis or keratitis.
- Injuries and ulcerous processes of cornea, especially infections caused by virus, bacteria and fungi.
- Dry eyes, especially keratoconjunctivitis sicca.
- Glaucoma.
Storage Condition
Store in a cool, dry place and protected from light. Keep out of the reach of children. Discard the container 4 weeks after opening.
Innovators Monograph
You find simplified version here Flosted
Flosted contains Fluorometholone see full prescribing information from innovator Flosted Monograph, Flosted MSDS, Flosted FDA label
FAQ
What is Flosted used for?
Flosted is used to treat eye conditions caused by inflammation (swelling). This medicine is a corticosteroid (steroid medicine) that helps reduce the swelling in the eye. Flosted is a synthetic glucocorticoid which is used in the treatment of inflammatory eye diseases. The C17α acetate ester, Flosted acetate, is also a glucocorticoid and is used for similar indications.
How safe is Flosted?
Use of this Flosted for prolonged periods or in high doses may cause serious eye problems (such as high pressure inside the eyes and cataracts). Tell your doctor right away if any of these unlikely but serious side effects occur: vision problems, eye pain. This medication may mask the signs of an eye infection.
How does Flosted work?
Flosted works by relieving symptoms such as swelling, redness, and itching. It belongs to a class of drugs known as corticosteroids.
What are the common side effects of Flosted?
Common side effects of Flosted are include :
- Bigger, dilated, or enlarged pupils (black part of the eye)
- blurred vision or other change in vision.
- burning, dry, or itching eyes.
- decreased vision.
- delayed wound healing.
- discharge from eye.
- headache.
- increased sensitivity of the eyes to light.
Is Flosted safe during pregnancy?
Use is not recommended. Animal studies have shown this drug to be embryocidal and teratogenic. There are no adequate and well-controlled studies in pregnant women.
Is Flosted safe during breastfeeding?
No information is available on the ophthalmic use of Flosted during breastfeeding. Because absorption from the eye is limited, ophthalmic Flosted would not be expected to cause any adverse effects in breastfed infants.
Can I drink alcohol with Flosted?
Moderate alcohol use may be safe during treatment with Flosted.
Can I drive after taking Flosted?
Eye drops can cause blurred vision when first put in. Do not drive and do not use tools or machines until your vision is clear again.
How often do I use Flosted ?
Adults, Use a small amount (1/2 inch ribbon) in the affected eye one to three times a day. During the first 24 to 48 hours, you may use this medicine every 4 hours, as directed by your doctor.
How long does Flosted take to work?
Unless you've been told otherwise, use the drops every hour you are awake until your symptoms are controlled, and then 2-4 times a day for a few days.
What is the half life of Flosted?
Small amounts may be absorbed into the cornea. Excreted rapidly in urine. Half-life: 7-13 hr.
Can I take Flosted for a long time?
Flosted eye drops are only meant to be used for a short period of time. Do not use them for longer than one week unless your doctor advises you otherwise. This is because they can cause problems within your eye when used for longer than recommended.
When should I stop taking eye drops?
The preservatives that keep them sterile only last for about 28 days, and should definitely be disposed of after three months.
Who should not take Flosted?
You should not use Flosted ophthalmic if you have any type of bacterial, fungal, or viral infection of the eye (including herpes). You should not use Flosted if you are allergic to it, or if you have any type of bacterial, fungal, or viral infection of the eye (including herpes). Tell your doctor if you have ever had: glaucoma; or cataracts. It is not known whether Flosted ophthalmic will harm an unborn baby. Tell your doctor if you are pregnant. You should not breast-feed while using this medicine.
What happens if I miss a dose?
Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
An overdose of Flosted ophthalmic is not expected to be dangerous. Seek emergency medical attention. If anyone has accidentally swallowed the medication.
Can Flosted cause high blood pressure?
Some of the more common side effects of Flosted include: increased pressure in your eye.
What happen If I stop taking Flosted?
If you stop using the drug or don't use it at all: If you don't use Flosted, your eye pain and inflammation won't improve and may get worse. If you miss doses or don't use the drug on schedule: Your medication may not work as well or may stop working completely.
