Flucloxacilina Labesfal

Flucloxacilina Labesfal Uses, Dosage, Side Effects, Food Interaction and all others data.

Flucloxacilina Labesfal inhibits the 3rd and last step of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. It is active against penicillinase-producing and non-penicillinase-producing staphylococci.

Flucloxacilina Labesfal is isoxazolyl penicillin which combined the properties of resistance to hydrolysis by penicillinase, gastric acid stability and activity against gram-positive bacteria. Flucloxacilina Labesfal is a bactericidal antibiotic that is particularly useful against penicillinase-producing staphylococci. Flucloxacilina Labesfal kills bacterial cellwall, thus interfering with peptidoglycan synthesis. Peptidoglycan is a heteropolymeric structure that provides the cell wall with its mechanical stability. The final stage of peptidoglycan synthesis involves the completion of the cross-linking with the terminal glycine residue of the pentaglycin bridge linking to the fourth residue of the pentapeptide (D-alanine). The transpeptidase enzyme that performs this step is inhibited by Flucloxacilina Labesfal. As a result the bacterial cellwall is weakened, the cell swells and then ruptures. Flucloxacilina Labesfal resists the action of bacterial penicillinase probably because of the steric hindrance induced by the acyl side chain which prevents the opening of the β- lactam ring.

Flucloxacilina Labesfal is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacilina Labesfal has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Flucloxacilina Labesfal results from the inhibition of cell wall synthesis and is mediated through flucloxacillin binding to penicillin binding proteins (PBPs). Flucloxacilina Labesfal is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Trade Name Flucloxacilina Labesfal
Generic Flucloxacillin
Flucloxacillin Other Names Floxacillin, Flucloxacilina, Flucloxacillin, Flucloxacilline, Flucloxacillinum
Type
Formula C19H17ClFN3O5S
Weight Average: 453.872
Monoisotopic: 453.056147271
Groups Approved, Investigational
Therapeutic Class Penicillinase-resistant penicillins
Manufacturer
Available Country Portugal
Last Updated: September 19, 2023 at 7:00 am
Flucloxacilina Labesfal
Flucloxacilina Labesfal

Uses

Flucloxacilina Labesfal is used for the treatment of infections due to Gram-positive organisms, including infections caused by β-lactamase producing staphylococci.

Skin and Soft Tissue Infections: Boils, abscesses, carbuncles, furunculosis,infected wounds, infected burns, protection of skin grafts, otitis media and externa, impetigo.

Infected Skin Conditions: Ulcer, eczema and acne.

Respiratory Tract Infections: Pneumonia, lung abscess, empyema, sinusitis,pharyngitis, tonsillitis, quinsy.

Other infections caused by Flucloxacilina Labesfal-sensitive organisms such as osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia.

Flucloxacilina Labesfal is also used for use as a prophylactic agent during major surgical procedures where appropriate, for example, cardiothoracic and orthopaedic surgery

Flucloxacilina Labesfal is also used to associated treatment for these conditions: Susceptible infections

How Flucloxacilina Labesfal works

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that flucloxacillin interferes with an autolysin inhibitor.

Dosage

Flucloxacilina Labesfal dosage

Oral administration:

Adult or Elderly:

  • Usual dosage: 250 mg four times daily. In severe infections, dosage should be doubled.
  • In osteomyelitis and endocarditis: up to 8 gm daily, in divided doses 6 to 8 hourly.
  • In case of secondary bacterial infection in chicken pox: Flucloxacilina Labesfal 500 mg six hourly should be prescribed.

Children:

  • Usual dosage: 2-10 years: half of the adult dose. Under 2 years: quarter of the adult dose.

Parenteral administration:

Adult or Elderly:

  • Intramuscular Injection: 250 mg four times daily.
  • Intravenous Injection: 250 mg-1 g four times daily by slow injection over 3 to 4 minutes or by intravenous infusion.
  • All systemic doses may be doubled in severe infections: doses up to 8 g daily have been suggested for endocarditis or osteomyelitis.

Children:

  • Usual dosage: 2-10 years : half of the adult dose. Under 2 years : quarter of the adult dose.

Doses should be administered half an hour before meals.

Flucloxacilina Labesfal has been used in other routes in conjunction with systemic therapy. It has been administered in a dose of 250 mg to 500 mg daily by intraarticular injection, dissolved if necessary in a 0.5% solution of lignocaine hydrochloride, and by intrapleural injection in a dose of 250 mg daily. Using powder for injection, 125 mg-250 mg has been dissolved in 3 ml of sterile water and inhaled by nebuliser four times daily.

Side Effects

There have been some common side effects of GIT such as nausea, vomiting, diarrhoea, dyspepsia and other minor gastrointestinal disturbances. Besides these rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis and cholestatic jaundice have been reported

Precaution

Patient with spirochaete infections (e.g. syphilis, leptospirosis), history of hypersensitivity to β-lactam antibiotics. Newborn infants. Hepatic or renal impairment. Pregnancy and lactation.

Interaction

The administration of probenecid with Flucloxacilina Labesfal results in higher serum peak concentrations and prolongs the time that therapeutic concentrations of Flucloxacilina Labesfal are achieved in serum. Physical incompatibility and/or loss of activity of Flucloxacilina Labesfal in solution has been reported when given with gentamycin sulphate, streptomycin sulphate, vitamin mixtures. Flucloxacilina Labesfal should not be added to intravenous lipids, blood products and protein hydrolysates or other proteinaceous fluids.

Food Interaction

  • Take on an empty stomach.

Elimination Route

Bioavailability is 50–70% following oral administration.

Half Life

0.75–1 hour

Pregnancy & Breastfeeding use

The use of Flucloxacilina Labesfal in pregnancy should be reserved for cases considered essential by the clinician. Use of the drug in the second and third trimesters may result in the sensitisation of the fetus. During lactation, trace quantities of penicillins can be detected in breast milk.

Contraindication

Flucloxacilina Labesfal is contraindicated for those who have hypersensitivity to penicillins.

Special Warning

Dose adjustment in renal impairment : As common with other penicillins, Flucloxacilina Labesfal usage in patients with renal impairment does not usually require dosage reduction. However, in the presence of severe renal failure (creatinine clearance < 10 ml/min) a reduction in dose or an extension of dose interval should be considered. Flucloxacilina Labesfal is not significantly removed by dialysis and hence no supplementary dosages need to be administered either during or at the end of the dialysis period.

Acute Overdose

Symptoms: Neurotoxicity (e.g. convulsions, encephalopathy), GI effects (e.g. nausea, vomiting, diarrhoea), blood disorders (e.g. neutropenia, haemolytic anaemia, prolongation of bleeding time, defective platelet function), electrolyte disturbances.

Management: Symptomatic treatment.

Storage Condition

Store below 25° C. Reconstituted solution: Store between 2-8°C.

Innovators Monograph

You find simplified version here Flucloxacilina Labesfal

Flucloxacilina Labesfal contains Flucloxacillin see full prescribing information from innovator Flucloxacilina Labesfal Monograph, Flucloxacilina Labesfal MSDS, Flucloxacilina Labesfal FDA label

FAQ

What is Flucloxacilina Labesfal used for?

Flucloxacilina Labesfal is an antibiotic used to treat skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and infection of bone. It may be used together with other medications to treat pneumonia, and endocarditis.

How safe is Flucloxacilina Labesfal?

It is normally very well tolerated but can be more likely than other antibiotics to cause heartburn. 

How does Flucloxacilina Labesfal work?

Flucloxacilina Labesfal works by interfering with the formation of the bacterial cell walls.

What are the common side effects of Flucloxacilina Labesfal?

The most common side effects are feeling sick (nausea) and diarrhoea. You can drink alcohol while taking Flucloxacilina Labesfal. You can take Flucloxacilina Labesfal during pregnancy or while you're breastfeeding.

Is Flucloxacilina Labesfal safe during pregnancy?

It is safe to take Flucloxacilina Labesfal during pregnancy.

Is Flucloxacilina Labesfal safe during breastfeeding?

It is safe to take Flucloxacilina Labesfal while breastfeeding. Information shows that only tiny amounts of Flucloxacilina Labesfal get into breast milk, which would not be expected to cause any side effects in your baby.

Can I drink alcohol with Flucloxacilina Labesfal?

Yes, you can drink alcohol while taking Flucloxacilina Labesfal.

How quickly does Flucloxacilina Labesfal take to work?

This means at least 30 to 60 minutes before a meal or snack, or at least 2 hours after. For most infections, you should start to feel better within a few days.

Can I take Flucloxacilina Labesfal on an empty stomach?

Flucloxacilina Labesfal is best taken on an empty stomach, one hour before eating food. This is because your body may absorb less Flucloxacilina Labesfal after a meal, making it less effective.

What is the half life of Flucloxacilina Labesfal?

The elimination half-life of Flucloxacilina Labesfal is in the order of 53 minutes.

How often can I take Flucloxacilina Labesfal?

The usual dose of Flucloxacilina Labesfal is 250mg to 500mg, taken 4 times a day.

Can I take Flucloxacilina Labesfal long term?

Keep taking Flucloxacilina Labesfal until you finish the pack, or for as long as your doctor recommends. Do not stop taking Flucloxacilina Labesfal, even if you feel better after a few days, unless advised by your doctor. Your infection may not clear completely if you stop taking your medicine too soon.

What happen If I stop taking Flucloxacilina Labesfal?

Do not stop taking Flucloxacilina Labesfal, even if you feel better after a few days, unless advised by your doctor. If you do not complete the full course prescribed by your doctor, the infection may not clear completely or your symptoms may return.

What happens if I miss a dose?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, plan to skip the missed dose and take your next dose as scheduled. Never double up on a dose. If you'd like more information about an antibiotic you've been prescribed, talk with your doctor or pharmacist.

What happens if I overdose?

Symptoms of an overdose may include nausea, vomiting and diarrhoea. If you take too much (overdose) Immediately telephone your doctor or the Poisons Information Centre for advice, or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else may have taken too much FLOPEN. Do this even if there are no signs of discomfort or poisoning.

Who should not take Flucloxacilina Labesfal?

You have pale poo with dark pee, and the whites of your eyes or skin turn yellow (this may be less obvious on black or brown skin) – this can be a sign of liver problems. you get bruising or discoloured skin. you have joint or muscle pain that starts happening after 2 days of taking the medicine.

Can Flucloxacilina Labesfal affect my kidneys?

Flucloxacilina Labesfal can injure the kidneys as well as the liver. Both interstitial nephritis and hepatitis are listed as very rare undesirable effects in the Flucloxacilina Labesfal data sheets.

Can Flucloxacilina Labesfal affects my liver?

Flucloxacilina Labesfal is now established as an important cause of cholestatic liver disease.

*** Taking medicines without doctor's advice can cause long-term problems.
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