Fluocinolone Acetonide
Fluocinolone Acetonide Uses, Dosage, Side Effects, Food Interaction and all others data.
Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.
Fluocinolone acetonide is a synthetic anti-inflammatory corticosteroid and thus, the effect of its interaction with the body produces vasoconstriction and suppression of membrane permeability, mitotic activity, immune response and release of inflammatory mediators.
For its ophthalmic indications, fluocinolone acetonide is administered as intravitreal micro-insert. This preparation was observed in clinical trials to reduce the recurrence of uveitis flares by 2 fold when compared with the non treated patients even after six months after initial administration. As well the intraocular pressure seemed to increase slightly with the presence of the fluocinolone implant but it is important to monitor intraocular pressure.
| Trade Name | Fluocinolone Acetonide |
| Generic | Fluocinolone Acetonide |
| Fluocinolone Acetonide Other Names | acétonide de fluocinolone, acetónido de fluocinolona, fluocinolon acetonid, Fluocinolone acetonide, fluocinoloni acetonidum |
| Type | |
| Formula | C24H30F2O6 |
| Weight | Average: 452.4882 Monoisotopic: 452.201045102 |
| Protein binding | This pharmacokinetic parameter is not relevant as the systemic absorption of fluocinolone acetonide is very minimal. |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Fluocinolone & Combined Preparations |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
This Cream and Ointment are suitable for treating a wide variety of local inflammatory, pruritic and allergic disorders of the skin.
This is particularly suitable for topical application in:
- Eczema and dermatitis: Atopic eczema, seborrhoeic eczema, discoid eczema, otitis externa, contact dermatitis, neurodermatitis.
- Prurigo, Psoriasis, lichen planus.
- Discoid lupus erythematosus.
Fluocinolone Acetonide is also used to associated treatment for these conditions: Acute Otitis Media, Allergy Skin, Anal Fissures, Atopic Dermatitis (AD), Blisters, Chronic Disease of Skin, Dermatosis, Diabetic Macular Edema (DME), External Hemorrhoid, Friction and Pressure Injuries, Hemorrhoids, Internal, Non-infectious Posterior Uveitis Chronic Uveitis, Otitis Externa, Perianal erythema, Pruritus, Psoriasis of the scalp, Purulent Wounds, Scab, Seborrheic dermatitis of the scalp, Skin Infections, Bacterial, Skin Inflammation caused by Bacterial Infections, Skin Inflammation of the ear, Uveitis, Wound Infections, Anal eczema, Chronic eczematous otitis externa, Corticosteroid-responsive dermatoses, Postoperative Care, Perioperative management therapy, Postoperative treatment
How Fluocinolone Acetonide works
Fluocinolone acetonide is a corticosteroid and thus, it can be inferred that it acts by inhibiting the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, collagen deposition, and scar formation.
Some reports have indicated that fluocinolone acetonide presents a high binding affinity for the glucocorticoid receptor. After binding the receptor, the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements in the promoter region of the target genes. This effect promotes the induction of phospholipase A2 inhibitory proteins (lipocortins). Through this mechanism of action, it is thought that fluocinolone induces mainly one of the lipocortins, annexin 1, which will later mediate the synthesis of inflammatory mediators such as prostaglandins and leukotrienes by inhibiting the release of arachidonic acid which is the precursor of all these inflammatory mediators. Hence, the induction of these proteins will prevent the release of arachidonic acid by phospholipase A2.
Dosage
Fluocinolone Acetonide dosage
A small quantity of Fluocinolone Acetonide is applied lightly up to 2 or 3 times a day, and massaged gently and thoroughly into the skin. These recommendations apply to both children and adults, including the elderly.
Side Effects
Side-effects are extremely rare, but as with all topical corticosteroids, patient may show hypersensitivity reaction.
Toxicity
Studies to determine the carcinogenic and its effect in fertility have not been performed. It is important to consider that several corticosteroids have been shown to present genotoxic potential but fluocinolone acetonide was shown to not be genotoxic in the Ames test and mouse lymphoma TK assay.
Precaution
Appropriate anti-infective cover should be given if there is an associated infection. Long term continuous topical steroid therapy can produce atrophic skin changes. Do not apply to the face for prolonged periods. Prolonged use or treatment of extensive areas can produce adrenal suppression, especially in infants and children.
Food Interaction
No interactions found.Volume of Distribution
This pharmacokinetic parameter is not relevant as the systemic absorption of fluocinolone acetonide is very minimal.
Elimination Route
When administered as an eye implant, fluocinolone acetonide presents a sustained delivery for even 12 months in which there can be observed a sustained release. The concentration of fluocinolone acetonide are generally higher in the vitreous and retina with a little dispersion to the aqueous humor.
There are reports indicating that topical administration of fluocinolone acetonide produces a percutaneous absorption which is determined by the vehicle, integrity of the epidermal barrier and the use of occlusive dressing.
Independently of the route of administration, the systemic absorption of fluocinolone acetonide is below 0.1 ng/ml which indicates that the systemic distribution is very minimal and the effect of fluocinolone is mainly local.
Half Life
The reported half-life of fluocinolone acetonide ranges between 1.3-1.7 hours.
Clearance
This pharmacokinetic parameter is not relevant as the systemic absorption of fluocinolone acetonide is very minimal and the concentration in urine is lower than the minimum quantitation limit.
Elimination Route
Fluocinolone acetonide is mainly excreted by the kidneys. It is important to mention that the systemically absorbed dose is very minimal.
Pregnancy & Breastfeeding use
Pregnancy: Topical administration of corticosteroids to pregnant animals can cause abnormalities of fetal development, including cleft palate intrauterine growth retardation. There may be a small risk of such effects on the human fetus.
Lactation: When topical steroid treatment is necessary, minimize amount and length of treatment.
Contraindication
Primary infections of the skin and in rosacea, acne, perioral dermatitis, anogenital pruritis and napkin eruption. Also known hypersensitivity to neomycin
Storage Condition
Store at temperature below 30° C.
Innovators Monograph
You find simplified version here Fluocinolone Acetonide
Fluocinolone Acetonide contains Fluocinolone Acetonide see full prescribing information from innovator Fluocinolone Acetonide Monograph, Fluocinolone Acetonide MSDS, Fluocinolone Acetonide FDA label
FAQ
What is Fluocinolone Acetonide used for?
Fluocinolone Acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. Fluocinolone Acetonide topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions.
How safe is Fluocinolone Acetonide?
Fluocinolone Acetonide generally safe. Also, avoid long-term use of this drug, and avoid using it over large areas of skin unless directed by your doctor. Use of Fluocinolone Acetonide cream raises your risk of skin infection. If you have a current infection or develop a new bacterial or fungal infection, tell your doctor right away.
How does Fluocinolone Acetonide work ?
Fluocinolone Acetonide works by decreasing your body's immune response to these diseases and reduces symptoms such as swelling.
What are the common side effects of Fluocinolone Acetonide?
Common side effects of Fluocinolone Acetonide are include:
- skin redness,
- burning,
- itching,
- irritation,
- excessive dryness,
- peeling,
- thinning of your skin,
- blistering skin,
Is Fluocinolone Acetonide safe during pregnancy?
Fluocinolone Acetonide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Topical corticosteroids should not be used extensively on pregnant patients, in large amounts or for extended periods of time.
Is Fluocinolone Acetonide safe during breastfeeding?
Yes, topically applied steroids are perfectly safe to use when you are breastfeeding.
When is the best time to take Fluocinolone Acetonide?
Fluocinolone Acetonide works best when it is given as close to the time of overdose as possible. The more time that goes by after the overdose, the less effective the medicine will be in protecting your liver.
How many times a day can I use Fluocinolone Acetonide?
Adults, Apply to the affected area of the skin two to four times per day. Children, Apply to the affected area of the skin two to four times per day.
How often can I take Fluocinolone Acetonide?
Fluocinolone Acetonide usually 2 to 4 times daily or as directed by your doctor.
How long does Fluocinolone Acetonide take to work?
A course of treatment for seven days is usually sufficient.
What is the half life of Fluocinolone Acetonide?
The elimination half-life of Fluocinolone Acetonide analysis 200–300 minutes (plasma), up to 36 hours (total).
Can I take Fluocinolone Acetonide for a long time?
Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.
How long can I use Fluocinolone Acetonide?
Do not use it for more than 2 weeks unless your doctor tells you otherwise.
Who should not use Fluocinolone Acetonide?
Fluocinolone Acetonide should only be used for skin conditions that your doctor is treating.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for a scheduled Fluocinolone Acetonide.
When Fluocinolone Acetonide is used as a single dose, you will not be on a regular dosing schedule.
What happens if I overdose?
Since Fluocinolone Acetonide is given by a healthcare professional in a medical setting, an overdose is unlikely to occur. Using too much Fluocinolone Acetonide is not likely to cause serious problems. However, long term use of high doses can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.
Can I stop taking Fluocinolone Acetonide?
This drug comes with risks if you don't use it as prescribed. If you stop using the drug suddenly or don't use it at all: Your symptoms, such as skin itching, redness, or swelling, may not improve or may get worse.
Can Fluocinolone Acetonide cause high blood pressure?
Cushing syndrome can also cause high blood sugar and high blood pressure.
Does Fluocinolone Acetonide cause weight gain?
unexplained weight gain may occurs.
Does Fluocinolone Acetonide lighten skin?
Fluocinolone Acetonide used to lighten the skin.
