Fluopromazine
Fluopromazine Uses, Dosage, Side Effects, Food Interaction and all others data.
A phenothiazine used as an antipsychotic agent and as an antiemetic.
Fluopromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspiciousness. Fluopromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Fluopromazine acts on the central nervous system.
| Trade Name | Fluopromazine |
| Availability | Discontinued |
| Generic | Triflupromazine |
| Triflupromazine Other Names | Fluopromazine, Triflupromazin, Triflupromazina, Triflupromazine, Triflupromazinum |
| Type | |
| Formula | C18H19F3N2S |
| Weight | Average: 352.417 Monoisotopic: 352.122103923 |
| Protein binding | Very high (90% or more). |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used mainly in the management of psychoses. Also used to control nausea and vomiting.
How Fluopromazine works
Fluopromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Fluopromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Fluopromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B).
Toxicity
Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.
Fluopromazine Alcohol interaction
[Moderate] GENERALLY AVOID:
Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.
Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.
The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
Patients should be advised to avoid alcohol during phenothiazine therapy.
Fluopromazine Drug Interaction
Moderate: diphenhydramine / ibuprofen, diphenhydramine, divalproex sodium, valsartan, budesonide / formoterolUnknown: mesalamine, calcium / vitamin d, pentosan polysulfate sodium, estradiol, guaifenesin, esomeprazole, sodium chloride, montelukast, ketorolac, fluticasone nasal, ascorbic acid
Fluopromazine Disease Interaction
Major: dementia, acute alcohol intoxication, cardiovascular disease, CNS depression, head injuryModerate: anticholinergic effects, breast cancer, dystonic reactions, hematologic toxicity, liver disease, NMS, parkinsonism, renal dysfunction, respiratory disorders, seizure disorders, tardive dyskinesia
Elimination Route
Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Innovators Monograph
You find simplified version here Fluopromazine
