Fluorescein sodium
Fluorescein sodium Uses, Dosage, Side Effects, Food Interaction and all others data.
Fluorescein sodium sodium responds to electromagnetic radiation and light between the wavelengths of 465- 490 nm and fluoresces, i.e., emits light at wavelengths of 520-530 nm. Thus, the hydrocarbon is excited by blue light and emits light that appears yellowish-green. Following intravenous injection of fluorescein sodium in an aqueous solution, the unbound fraction of the fluorescein can be excited with a blue light flash from a fundus camera as it circulates through the ocular vasculature, and the yellowish green fluorescence of the dye is captured by the camera. In the fundus, the fluorescence of the dye demarcates the retinal and/or choroidal vasculature under observation, distinguishing it from adjacent areas/structures.
| Trade Name | Fluorescein sodium |
| Availability | Prescription only |
| Generic | Fluorescein |
| Fluorescein Other Names | Fluorescein, Fluoresceina, Fluoresceína, Fluoresceine, Fluoreszein, Resorcinolphthalein, Yellow fluorescein |
| Type | |
| Formula | C20H12O5 |
| Weight | Average: 332.3063 Monoisotopic: 332.068473494 |
| Protein binding | 85% |
| Groups | Approved |
| Therapeutic Class | Preparations for Ophthalmic diagnosis |
| Manufacturer | SERB |
| Available Country | United Kingdom |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Fluorescein sodium does not stain a normal cornea but conjunctival abrasions are stained yellow or orange, corneal abrasions or ulcers are stained a bright green and foreign bodies are surrounded by a green ring. Fluorescein sodium can be used in diagnostic examinations including Goldmann tonometry and in the fitting of hard contact lenses
Fluorescein sodium is also used to associated treatment for these conditions: Peritoneal dialysis therapy, Pneumocystis Jirovecii Pneumonia
How Fluorescein sodium works
Fluorescein sodium sodium is used extensively as a diagnostic tool in the field of ophthalmology. Fluorescein sodium is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Fluorescein sodium angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors.
Dosage
Fluorescein sodium dosage
Ophthalmic-Aid in the fitting of hard contact lenses, Detection of corneal lesions and foreign bodies, Diagnostic ophthalmic procedures:
- Adult: Apply 1% or 2% solution as eye drops or as sterile papers impregnated with fluorescein sodium. May also be given in combination with a local anaesthetic: as a 0.25% solution with oxybuprocaine HCl or proxymetacaine HCl.
Side Effects
Nausea and vomiting (IV); extravasation is painful; hypersensitivity reactions; transient yellow coloration of skin and urine; staining of the skin, clothing and soft contact lenses.
Precaution
Special care should be taken to avoid microbial contamination. Pseudomonas aeruginosa grows well in fluorescein solutions, therefore, a single dose solution is preferred.
Food Interaction
No interactions found.Fluorescein sodium Drug Interaction
Moderate: sotalol, sotalolUnknown: aspirin, aspirin, charcoal, charcoal, heparin, heparin, acetaminophen, acetaminophen, procaine penicillin, procaine penicillin, vitamin a topical, vitamin a topical, bioflavonoids, bioflavonoids, valproic acid, valproic acid, pyridoxine, pyridoxine
Fluorescein sodium Disease Interaction
Volume of Distribution
- 0.5 L/kg
Elimination Route
Rapidly distributed
Clearance
- renal cl=1.75 mL/min/kg [After IV administration]
- hepatic cl=1.50 mL/min/kg [After IV administration]
Elimination Route
Fluorescein sodium and its metabolites are mainly eliminated via renal excretion.
Pregnancy & Breastfeeding use
Safety for use in pregnancy and lactation has not been established, therefore use only when considered essential by the physician
Contraindication
Acute necrotising pancreatitis (oral fluorescein dilaurate).
Storage Condition
Store below 25°C. Do not freeze. Protect from light.
Innovators Monograph
You find simplified version here Fluorescein sodium
Fluorescein sodium contains Fluorescein see full prescribing information from innovator Fluorescein sodium Monograph, Fluorescein sodium MSDS, Fluorescein sodium FDA label
