Fluorescien

Fluorescien Uses, Dosage, Side Effects, Food Interaction and all others data.

Fluorescien sodium responds to electromagnetic radiation and light between the wavelengths of 465- 490 nm and fluoresces, i.e., emits light at wavelengths of 520-530 nm. Thus, the hydrocarbon is excited by blue light and emits light that appears yellowish-green. Following intravenous injection of fluorescein sodium in an aqueous solution, the unbound fraction of the fluorescein can be excited with a blue light flash from a fundus camera as it circulates through the ocular vasculature, and the yellowish green fluorescence of the dye is captured by the camera. In the fundus, the fluorescence of the dye demarcates the retinal and/or choroidal vasculature under observation, distinguishing it from adjacent areas/structures.

Fluorescien
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Fluorescien
Availability	Prescription only
Generic	Fluorescein
Fluorescein Other Names	Fluorescein, Fluoresceina, Fluoresceína, Fluoresceine, Fluoreszein, Resorcinolphthalein, Yellow fluorescein
Weight	1%w/v, 2%w/v
Type	Eye Drops
Formula	C₂₀H₁₂O₅
Weight	Average: 332.3063 Monoisotopic: 332.068473494
Protein binding	85%
Groups	Approved
Therapeutic Class	Preparations for Ophthalmic diagnosis
Manufacturer	Novartis Pharma (pak) Ltd
Available Country	Pakistan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Fluorescien does not stain a normal cornea but conjunctival abrasions are stained yellow or orange, corneal abrasions or ulcers are stained a bright green and foreign bodies are surrounded by a green ring. Fluorescien can be used in diagnostic examinations including Goldmann tonometry and in the fitting of hard contact lenses

Fluorescien is also used to associated treatment for these conditions: Peritoneal dialysis therapy, Pneumocystis Jirovecii Pneumonia

How Fluorescien works

Fluorescien sodium is used extensively as a diagnostic tool in the field of ophthalmology. Fluorescien is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Fluorescien angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors.

Dosage

Fluorescien dosage

Ophthalmic-Aid in the fitting of hard contact lenses, Detection of corneal lesions and foreign bodies, Diagnostic ophthalmic procedures:

Adult: Apply 1% or 2% solution as eye drops or as sterile papers impregnated with fluorescein sodium. May also be given in combination with a local anaesthetic: as a 0.25% solution with oxybuprocaine HCl or proxymetacaine HCl.

Side Effects

Nausea and vomiting (IV); extravasation is painful; hypersensitivity reactions; transient yellow coloration of skin and urine; staining of the skin, clothing and soft contact lenses.

Precaution

Special care should be taken to avoid microbial contamination. Pseudomonas aeruginosa grows well in fluorescein solutions, therefore, a single dose solution is preferred.