Fluorescien

Fluorescien Uses, Dosage, Side Effects, Food Interaction and all others data.

Fluorescien sodium responds to electromagnetic radiation and light between the wavelengths of 465- 490 nm and fluoresces, i.e., emits light at wavelengths of 520-530 nm. Thus, the hydrocarbon is excited by blue light and emits light that appears yellowish-green. Following intravenous injection of fluorescein sodium in an aqueous solution, the unbound fraction of the fluorescein can be excited with a blue light flash from a fundus camera as it circulates through the ocular vasculature, and the yellowish green fluorescence of the dye is captured by the camera. In the fundus, the fluorescence of the dye demarcates the retinal and/or choroidal vasculature under observation, distinguishing it from adjacent areas/structures.

Trade Name Fluorescien
Availability Prescription only
Generic Fluorescein
Fluorescein Other Names Fluorescein, Fluoresceina, Fluoresceína, Fluoresceine, Fluoreszein, Resorcinolphthalein, Yellow fluorescein
Weight 1%w/v, 2%w/v
Type Eye Drops
Formula C20H12O5
Weight Average: 332.3063
Monoisotopic: 332.068473494
Protein binding

85%

Groups Approved
Therapeutic Class Preparations for Ophthalmic diagnosis
Manufacturer Novartis Pharma (pak) Ltd
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Fluorescien
Fluorescien

Uses

Fluorescien does not stain a normal cornea but conjunctival abrasions are stained yellow or orange, corneal abrasions or ulcers are stained a bright green and foreign bodies are surrounded by a green ring. Fluorescien can be used in diagnostic examinations including Goldmann tonometry and in the fitting of hard contact lenses

Fluorescien is also used to associated treatment for these conditions: Peritoneal dialysis therapy, Pneumocystis Jirovecii Pneumonia

How Fluorescien works

Fluorescien sodium is used extensively as a diagnostic tool in the field of ophthalmology. Fluorescien is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Fluorescien angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors.

Dosage

Fluorescien dosage

Ophthalmic-Aid in the fitting of hard contact lenses, Detection of corneal lesions and foreign bodies, Diagnostic ophthalmic procedures:

  • Adult: Apply 1% or 2% solution as eye drops or as sterile papers impregnated with fluorescein sodium. May also be given in combination with a local anaesthetic: as a 0.25% solution with oxybuprocaine HCl or proxymetacaine HCl.

Side Effects

Nausea and vomiting (IV); extravasation is painful; hypersensitivity reactions; transient yellow coloration of skin and urine; staining of the skin, clothing and soft contact lenses.

Precaution

Special care should be taken to avoid microbial contamination. Pseudomonas aeruginosa grows well in fluorescein solutions, therefore, a single dose solution is preferred.

Food Interaction

No interactions found.

Fluorescien Disease Interaction

Moderate: bronchial asthma

Volume of Distribution

  • 0.5 L/kg

Elimination Route

Rapidly distributed

Clearance

  • renal cl=1.75 mL/min/kg [After IV administration]
  • hepatic cl=1.50 mL/min/kg [After IV administration]

Elimination Route

Fluorescien and its metabolites are mainly eliminated via renal excretion.

Pregnancy & Breastfeeding use

Safety for use in pregnancy and lactation has not been established, therefore use only when considered essential by the physician

Contraindication

Acute necrotising pancreatitis (oral fluorescein dilaurate).

Storage Condition

Store below 25°C. Do not freeze. Protect from light.

Innovators Monograph

You find simplified version here Fluorescien

Fluorescien contains Fluorescein see full prescribing information from innovator Fluorescien Monograph, Fluorescien MSDS, Fluorescien FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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