Fluphenazine Hydrochloride Pharmaceutical Associates
Fluphenazine Hydrochloride Pharmaceutical Associates Uses, Dosage, Side Effects, Food Interaction and all others data.
Fluphenazine Hydrochloride Pharmaceutical Associates blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Fluphenazine Hydrochloride Pharmaceutical Associates is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine Hydrochloride Pharmaceutical Associates has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Trade Name | Fluphenazine Hydrochloride Pharmaceutical Associates |
Availability | Prescription only |
Generic | Fluphenazine |
Fluphenazine Other Names | Flufenazina, Fluorfenazine, Fluorophenazine, Fluorphenazine, Fluphenazin, Fluphénazine, Fluphenazine, Fluphenazinum, Triflumethazine |
Related Drugs | haloperidol, prochlorperazine, Haldol, Compazine, chlorpromazine, Thorazine |
Type | |
Formula | C22H26F3N3OS |
Weight | Average: 437.522 Monoisotopic: 437.174867774 |
Groups | Approved |
Therapeutic Class | Phenothiazine drugs |
Manufacturer | |
Available Country | USA |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
In the long-term management of psychotic disorders including:
- Schizophrenia
- Mania and
- Organic brain syndrome.
Fluphenazine Hydrochloride Pharmaceutical Associates is also used to associated treatment for these conditions: Chorea, Depression, Gilles de la Tourette's Syndrome, Psychosis, Sedation
How Fluphenazine Hydrochloride Pharmaceutical Associates works
Fluphenazine Hydrochloride Pharmaceutical Associates blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Dosage
Fluphenazine Hydrochloride Pharmaceutical Associates dosage
Fluphenazine Hydrochloride Pharmaceutical Associates Decanoate by deep intramuscular injection into the gluteal muscle, test dose 12.5 mg (6.25 mg in elderly), then after 4-7 days 12.5-100 mg repeated at intervals of 14-35 days, adjusted according to response; it is not recommended for children.
Side Effects
The side effects include tardive dyskinesia, sedation, mental confusion; hypotension; hyperprolactinaemia leading to galactorrhoea and amenorrhoea in women; loss of libido, impotence and sterility in males. Also include allergic reactions, cholestatic jaundice, corneal and lens deposists, skin pigmentation. Other potential adverse reactions are agranulocytosis; neuroleptic syndrome.
Precaution
Special precaution should be practiced in presence of convulsive disorders; hepatic, renal, cerebrovascular, respiratory and cardiovascular diseases. Also precaution should be observed in case of phenochromocytoma; bone marrow suppression; elderly or debilitated patients.
Interaction
Fluphenazine Hydrochloride Pharmaceutical Associates reverses antihypertensive effects of Guanethidine, Methyldopa and Clonidine. It also causes lithium toxicity by interacting with it. Antacids may reduce bioavailability of phenothiazines. Additive CNS depressant effects produced with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.
Food Interaction
- Avoid alcohol.
- Take with food. Food reduces irritation.
Fluphenazine Hydrochloride Pharmaceutical Associates Alcohol interaction
[Moderate] GENERALLY AVOID:
Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.
Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.
The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
Patients should be advised to avoid alcohol during phenothiazine therapy.
Fluphenazine Hydrochloride Pharmaceutical Associates Drug Interaction
Major: escitalopram, escitalopramModerate: aripiprazole, aripiprazole, lorazepam, lorazepam, benztropine, benztropine, lamotrigine, lamotrigine, lurasidone, lurasidone, quetiapine, quetiapine, sertraline, sertraline, olanzapine, olanzapineUnknown: cholecalciferol, cholecalciferol
Fluphenazine Hydrochloride Pharmaceutical Associates Disease Interaction
Major: dementia, acute alcohol intoxication, cardiovascular disease, CNS depression, head injuryModerate: anticholinergic effects, breast cancer, dystonic reactions, hematologic toxicity, liver disease, NMS, parkinsonism, renal dysfunction, respiratory disorders, seizure disorders, tardive dyskinesia
Pregnancy & Breastfeeding use
The safety for the use of Fluphenazine Hydrochloride Pharmaceutical Associates decanoate during pregnancy has not yet been established; therefore the possible hazards should be weighed against the potential benefits when administering this drug to pregnant patients.
Contraindication
Fluphenazine Hydrochloride Pharmaceutical Associates Decanoate oily Injection is contraindicated in patients with hypersensitivity to the drug. Also contraindicated in comatose or severely depressed states, blood dyscrasias, liver disease, pregnancy (3rd trimester), lactation.
Storage Condition
Store at 15-30°C.
Innovators Monograph
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Fluphenazine Hydrochloride Pharmaceutical Associates contains Fluphenazine see full prescribing information from innovator Fluphenazine Hydrochloride Pharmaceutical Associates Monograph, Fluphenazine Hydrochloride Pharmaceutical Associates MSDS, Fluphenazine Hydrochloride Pharmaceutical Associates FDA label