Fluprisan Sr

Fluprisan Sr Uses, Dosage, Side Effects, Food Interaction and all others data.

Fluprisan Sr is a pyridine derivative that is in clinical use as a nonopioid analgesic. It was approved for the treatment of pain in 1984 in Europe. It is not approved for use in the U.S. or Canada, but is currently in phase II trials for the treatment of fibromyalgia.

Trade Name Fluprisan Sr
Generic Flupirtine
Flupirtine Other Names Flupirtine, Flupirtino, Flupirtinum
Type Tablet
Formula C15H17FN4O2
Weight Average: 304.3195
Monoisotopic: 304.133554013
Groups Investigational
Therapeutic Class
Manufacturer Unichem Laboratories Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Fluprisan Sr
Fluprisan Sr

Uses

Investigated for use/treatment in fibromyalgia.

How Fluprisan Sr works

Fluprisan Sr upregulates Bcl-2, increases glutathione levels, activates an inwardly rectifying potassium channel, and delays loss of intermitochondrial membrane calcium retention capacity. Fluprisan Sr acts like a NMDA receptor antagonists, but does not bind to the receptor. One study concluded that the discriminative effects of flupirtine are neither of opioid nor of alpha-1 adrenergic type, but are primarily mediated through alpha-2 adrenergic mechanisms [PMID: 2901483].

Toxicity

Oral, mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 980 mg/kg.

Elimination Route

Bioavailability: 90% (oral), 70% (rectal)

Half Life

6.5 hrs (average), 11.2-16.8 hrs (average 14 hrs) (elderly), 8.7-10.9 hrs (average 9.8 hrs) (in those with moderate-level renal impairment).

Elimination Route

72% of flupirtine and its metabolites appear in urine and 18% appear in faeces.

Innovators Monograph

You find simplified version here Fluprisan Sr

*** Taking medicines without doctor's advice can cause long-term problems.
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