Fonx 1%

Uses

Fonx 1% cream is used for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum. Fonx 1% Cream is used for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur.

Fonx 1% is also used to associated treatment for these conditions: Fungal skin infection, Pityriasis versicolor, Tinea Corporis, Tinea Cruris, Tinea Pedis

How Fonx 1% works

Fonx 1% inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Fonx 1% has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Fonx 1% can increase membrane permeability to zinc, augmenting its cytotoxicity.

Dosage

Fonx 1% dosage

Cream should be applied to affected and immediately surrounding areas once to twice daily in patients with tinea pedis, tinea corporis, or tinea cruris. Fonx 1%Cream should be applied once daily in the treatment of tinea (pityriasis) versicolor. Tinea corporis, tinea cruris, and tinea (pityriasis) versicolor should be treated for 2 weeks and tinea pedis for 1 month to reduce the possibility of recurrence.

Use Fonx 1% cream as directed by the physician. The hands should be washed after applying the medication to the affected area(s). Avoid contact with the eyes, nose, mouth, and other mucous membranes. Fonx 1% cream isfor external use only.

Use the medication for the full treatment time recommended by the physician, even though symptoms may have improved. Notify the physician if there is no improvement after 2 to 4 weeks orsooner if the condition worsens.

Inform the physician if the area of application shows signs of increased irritation, itching, burning, blistering, swelling, or oozing.

Avoid the use of occlusive dressings unless otherwise directed by the physician.

Do not use this medication for any disorder other than that for which it was prescribed

Side Effects

Pruritus, burning, irritation and allergic contact dermatitis, folliculitis, erythema, and papules, fissure, maceration, rash, stinging and nodules.

Toxicity

Side effects incliude pruritus, burning, irritation, erythema, stinging and allergic contact dermatitis and folliculitis, fissuring, maceration rash and nodules.

Precaution

Fonx 1% cream is not for ophthalmic or intravaginal use.

Interaction

Potential drug interactions between Fonx 1% and other drugs have not been systematically evaluated.

Food Interaction

Elimination Route

Systemic absorption of oxiconazole is low.

Pregnancy & Breastfeeding use

Pregnancy category B. Because Fonx 1% Nitrate is excreted in human milk, caution should be exercised when the drug is administered to a nursing woman.

Contraindication

Fonx 1% cream is contraindicated in individuals who have shown previous hypersensitivity to Fonx 1%

Storage Condition

Store in a cool and dry place,protected from light. Do not freeze.

Innovators Monograph

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