Foohol
Foohol Uses, Dosage, Side Effects, Food Interaction and all others data.
Foohol is an azole antifungal drug.
Foohol is a type of antifungal medicine known as an imidazole. It kills fungi and yeasts by interfering with their cell membranes.
| Trade Name | Foohol |
| Generic | Bifonazole |
| Bifonazole Other Names | Bifonazol, Bifonazole, Bifonazolum |
| Type | |
| Formula | C22H18N2 |
| Weight | Average: 310.3917 Monoisotopic: 310.146998586 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Taiwan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Foohol is an azole antifungal drug used to treat fungal skin infections, such as dermatomycosis.
Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis).
Foohol is also used to associated treatment for these conditions: Dermatomycoses, Fungal infection of nail, Infections, Fungal, Infections, Fungal of the Skin Folds
How Foohol works
Foohol works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes.It acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.
Elimination Route
Very low absorption following topical administration (0.6% of an applied dose). In cases of skin lesions absorption is increased (2.5%).
Half Life
1-2 hours
Innovators Monograph
You find simplified version here Foohol
