Fosfomax 4 gm/vial IV Infusion Uses, Dosage, Side Effects and more
| Trade Name | Fosfomax 4 gm/vial IV Infusion |
| Generic | Fosfomycin Sodium |
| Weight | 4 gm/vial |
| Type | IV Infusion |
| Therapeutic Class | Intracellular antibiotic |
| Manufacturer | Square Pharmaceuticals Ltd. |
| Available Country | Bangladesh |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Fosfomycin Infusion is indicated for the treatment of the following infections in adults and children including neonates: Osteomyelitis Complicated urinary tract infections Nosocomial lower respiratory tract infections Bacterial meningitis Bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above ... Read moreDosage
Fosfomax 4 gm/vial IV Infusion dosage
The daily dose of Fosfomycinis determined based on the indication, severity and site of the infection, susceptibility of the pathogen(s) to fosfomycin and the renal function.In children,it is also determined by age and body weight.Adults and adolescents >12 years of age (>40 kg): Fosfomycin is primarily excreted renally unchanged. The general dosage guidelines for adults with estimated creatinine clearance >80 ml/min are as follows: Osteomyelitis: 12-24 gm in 2-3 divided doses Complicated urinary tract infection: 12-16 gm in 3 divided dose Nosocomial lower respiratory tract infection: 12-24 gm in 2-3 divided dose Bacterial meningitis: 16-24 gm in 3-4 divided doses Individual doses must not exceed 8 gm. The high-dose regimen in 3 divided doses should be used in severe infections expected or known to be caused by less susceptible bacteria. There are limited safety data in particular for doses in excess of 16 g/day. Special caution is advised when such doses are prescribed.Dosage in renal insufficiency: Special precaution should be exercised if doses at the higher end of the recommended range are considered. In patients with impaired renal function the dose of fosfomycin must be adjusted to the degree of renal impairment.Hepatic impairment: There are no data indicating that dose adjustment is necessary in patients with hepatic impairment.Elderly patients: The recommended doses for adults should be used in elderly patients. Caution is advised when considering the use of doses at the higher end of the recommended range.Pediatric population: Dose recommendations are based on very limited data.Neonates, infants and children <12 years of age (<40 kg): The dosage of fosfomycin in children should be based on age and body weight (BW): Premature neonates (age <40 weeks): 100 mg/kg BW in 2 divided doses Neonates (age 40-44 weeks): 200 mg/kg BW in 3 divided doses Infants 1-12 months (up to 10 kg BW): 200-300 b mg/kg BW in 3 divided doses Infants and children aged1-12 years (10-40 kg BW): 200-400 b mg/kg BW in 3-4 divided doses Method of administration: Fosfomax 4 gm/vial IV Infusion is intended for intravenous administration. The duration of infusion should be at least 30 minutes for the 4 gm pack size. Use only clear solutions.Preparation of the solution for infusion: Fosfomax 4 gm/vial IV Infusion must be reconstituted and diluted prior to administration. Water for Injections and Glucose Infusion 50 mg/ml (5%) or Glucose Infusion 100 mg/ml (10%) may be used as solvent for the reconstitution and dilution. Sodium Chloride containing solvents must not be used.Reconstitution: Shake the vial prior to the reconstitution to loosen up the powder. Reconstitute the 4 gm vials with 20 ml of solvent. Shake well to dissolve. A slight degree of warming occurs when the powder is dissolved.Dilution: Transfer the reconstituted contents of 4 gm vials into an infusion container with further 80 ml of solvent. The resulting solution for infusion is clear and colorless to slightly yellowish.Duration of treatment: Treatment duration should take into account the type of infection, the severity of the infection as well as the patient's clinical response.
