Frexocel
Frexocel Uses, Dosage, Side Effects, Food Interaction and all others data.
Frexocel is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver failure. New Zealand and Canada have also followed suit in recalling the drug.
Frexocel has a different structure from the standard COX-2 inhibitors (e.g. celecoxib). It more closely resembles the structure of diclofenac (one chlorine substituted by fluorine, the phenylacetic acid has another methyl group in meta position), making it a member of the arylalkanoic acid family of NSAIDs. It binds to a different site on the COX-2 receptor than the standard COX-2 inhibitors. It displays extremely high COX-2 selectivity.
Trade Name | Frexocel |
Generic | Lumiracoxib |
Lumiracoxib Other Names | Lumiracoxib, Lumiracoxibum |
Type | |
Formula | C15H13ClFNO2 |
Weight | Average: 293.721 Monoisotopic: 293.061884577 |
Protein binding | Highly bound to plasma proteins (>= 98%). |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | Laboratório Normal - Produtos Farmacêuticos, SA |
Available Country | Portugal |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults.
How Frexocel works
The mechanism of action of lumiracoxib is due to inhibition of prostaglandin synthesis via inhibition of cyclooygenase-2 (COX-2). Frexocel does not inhibit COX-1 at therapeutic concentrations.
Toxicity
Single oral doses in mice and rats resulted in mortality and/or moribundity at doses of 600 mg/kg and 500 mg/kg, respectively. Single intraperitoneal doses in mice and rats results in mortality/moribundity at 750 mg/kg and 1000 mg/kg, respectively. The maximum non-lethal single oral and intraperitoneal dose in mouse was 300 mg/kg and 250 mg/kg, respectively. In the rat it was 150 mg/kg and 250 mg/kg, respectively.
Food Interaction
- Take with or without food. The absorption is unaffected by food.
Elimination Route
Rapidly absorbed following oral administration, with an absolute oral bioavailablity of 74%.
Half Life
Terminal half-life is approximately 4 hours.
Innovators Monograph
You find simplified version here Frexocel