Fulyzaq

Fulyzaq Uses, Dosage, Side Effects, Food Interaction and all others data.

Fulyzaq, previously known as the investigational drug SP-303, is a novel proanthocyanidin purified from the bark latex of the Amazonian Croton tree Croton lechleri. It is marketed under the brand name Fulyzaq and indicated for the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.

Fulyzaq is an inhibitor of secretory diarrhea via inhibition of the CFTR chloride transporter. Fulyzaq is not an antimicrobial, and therefore does not drive the emergence of resistance; it does not inhibit motility, and therefore does not cause constipation or rebound diarrhea; and it is not systemically absorbed, reducing the potential for adverse drug interactions and toxicity.

Fulyzaq
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Fulyzaq
Availability	Prescription only
Generic	Crofelemer
Crofelemer Other Names	Crofelemer
Related Drugs	loperamide, Lomotil, Imodium, neomycin, Pepto-Bismol, bismuth subsalicylate
Weight	125mg,
Type	Oral Delayed Release Tablet, Tablet, Coated
Protein binding	Since crofelemer is not significantly absorbed, protein binding was not quantified.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Fulyzaq is an antidiarrheal agent used for the symptomatic relief of drug-induced non-infectious diarrhea in adult patients with HIV/AIDS receiving antiretroviral therapy.

For the symptomatic treatment of non-infectious diarrhea in adult patients with HIV/AIDS who are taking antiretroviral therapy.

Fulyzaq is also used to associated treatment for these conditions: Non-infectious Diarrhea

How Fulyzaq works

Fulyzaq is an inhibitor of the cystic fibrosis transmembrane regulator chloride channel (CFTR), as evidenced by its activity on cell cultures, single cell patch clamps, single CFTR channels, and elaboration of mouse intestinal fluid secretion. Fulyzaq also inhibits calcium activated chloride channels (CaCC), which in combination with CFTR, are expressed on the luminal side of intestinal cells. Fulyzaq inhibition of both of these channels prevents water loss from diarrhea by inhibiting chloride secretion.