Fusate
Fusate Uses, Dosage, Side Effects, Food Interaction and all others data.
Fusate, an antibiotic derived from Fusidium coccineum, exerts powerful activity against a number of gram-positive organisms. Staphylococci, including the strains resistant to penicillin or other antibiotics, are particularly susceptible to Fusate. The therapeutic efficacy of topically applied Fusate is due partly to the pronounced antibacterial activity of Fusate against the organisms responsible for skin infection and partly to the unique ability of this antibiotic to penetrate intact skin.
Fusidic Acid is an anti-microbial agent that acts as an inhibitor of protein synthesis in the microorganism. It interferes with the translocation step by stabilizing the ribosome-guanosine dephosphate elongation factor G-complex. This prevents binding of aminoacyl t-RNA to the ribosome and thereafter stops transfer of additional amino acids to the growing polypeptide.
Fusidic acid inhibits bacterial protein synthesis by interfering with amino acid transfer from aminoacyl-tRNA to protein on the ribosomes.
Fusidicacidinhibitsbacterialproteinsynthesisbyinterferingwithaminoacidtransferfromaminoacyl-tRNAtoproteinontheribosomes.
| Trade Name | Fusate |
| Generic | Sodium Fusidate |
| Weight | 2% |
| Type | Cream |
| Therapeutic Class | Other antibiotic |
| Manufacturer | Amulet Pharmaceuticals Ltd |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Fusate Ointment is used for treatment of skin infections caused by Staphylococci, Streptococci, Corynebacterium minutissimum and other Fusidate sensitive organisms. The most important indications being: impetigo, boils, abscess, varicose ulcers, skin grafts, hidradenitis, infected wounds, sycosis barbae, paronychia, folliculitis, carbuncles and erythrasma.
Treatment of infections caused by susceptible organisms especially Staph eg, osteomyelitis, septicaemia, endocarditis, superinfected cystic fibrosis, pneumonia, skin & soft tissue infections, surgical & traumatic wound infections.
Dosage
Fusate dosage
Fusate Ointment or cream is applied to the affected areas 2 to 3 times daily, generally for a period of 7 days. It can be used with or without a covering dressing. Caution should be observed when applying Fusate Ointment near the eye region as this preparation may cause irritation if it gets into the eye. No special dosage modifications or special precautions are required for children.
Adult:250-500 mg every 8 hourly
Skin & soft tissue infection: 250 mg twice daily.
Side Effects
Fusate Ointment is remarkably well tolerated, and there is an extremely low frequency of hypersensitivity reactions.
GI disturbances eg, dyspepsia, nausea, vomiting, epigastric pain, anorexia; jaundice & change of liver function.
Precaution
Hepatic impairment, biliary obstruction or disease. Monitor hepatic function periodically in patients on high or prolonged oral doses. Avoid during 3rd trimester of pregnancy. Lactation. Premature, jaundiced, acidotic or seriously ill neonates.
Caution should be observed when applying Fusate ointment in the eye region as this preparation may cause irritation upon contact with the eye.
Interaction
Drugs metabolized by CYP450 isoenzymes.
Contraindication
Known hypersensitivity to Fusate, severe hepatic failure.
Innovators Monograph
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FAQ
What is Fusate used for?
Fusate used to treat bone infections caused by this germ. It works by stopping the growth of the germs.Fusate is also prescribed for other infections caused by staphylococcal germs, such as some skin infections.
How safe is Fusate?
Don't use Fusate for longer than prescribed, or save it for treating future infections, unless instructed to by your doctor. Prolonged or repeated use of antibacterial medicines can cause skin reactions and may also result in the bacteria becoming resistant to the medicine.
What are the common side effects of Fusate?
The most common side effects of Fusate eye drops are dry, sore, itchy or stinging eyes. You may also get blurred vision.
Is Fusate safe during pregnancy?
No effects during pregnancy are anticipated, since systemic exposure to topically-applied Fusate is negligible. Topical Fucidin can be used during pregnancy.
Is Fusate safe during breastfeeding?
It's generally safe to use fusidic acid cream, ointment or eye drops while you're breastfeeding. If you're breastfeeding, take care when you put on Fusate cream or ointment.
Is Fusate good for skin infection?
It is used to treat various skin infections caused by certain kinds of bacteria. Such infections may include impetigo and secondary infections to burns or broken skin.
Is Fusate good for wounds?
Fusate made to be put directly on skin and wounds.
Is Fusate good for wounds?
Fusate ointment is made to be put directly on skin and wounds.
Does Fusate help pimples?
Topical Fusate is occasionally used as a treatment for acne vulgaris. As a treatment for acne, Fusate is often partially effective at improving acne symptoms.
Is good for fungal infection?
Fusate is not active against fungal skin infections.
When should I not use Fusate?
Fusate is not recommended in the following conditions: atrophic skin, cutaneous ulcer, acne vulgaris, fragile skin veins and perianal and genital pruritus.
How many days should I use Fusate?
Only use it for as long as your doctor has instructed you to. A course of treatment typically lasts for around seven days. You should not use the cream or ointment for longer than 10 days.
Is Fusate good for a rash?
Fusate used to treat mild to moderately severe atopic (allergic) dermatitis rashes.
How do I use Fusate?
Fusate is also prescribed for other infections caused by staphylococcal germs.
How many times a day can I use Fusate?
Fusate used usual to put on fusidic acid cream or ointment 3 or 4 times a day.
Does Fusate stop itching?
It reduces the swelling, redness and itching and so helps prevent scratching that can further irritate the skin.
How should I use Fusate?
Apply a small amount to the affected area 2 to 3 times daily for 7 to 14 days. If your doctor has directed you to cover the lesion with a gauze dressing, you may be directed to apply the medication only 1 or 2 times daily.
What happen If I missed Fusate?
If you miss a dose, apply it as soon as remembered; do not apply it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not double-up the dose to catch up.
What happen If I overdose of Fusate?
If overdose is suspected, contact your local poison control center or emergency room immediately. This medicine may be harmful if swallowed.
