Fusidic Acid Sinphar
Fusidic Acid Sinphar Uses, Dosage, Side Effects, Food Interaction and all others data.
Fusidic acid is an antimicrobial agent that inhibits bacterial protein synthesis. Fusidic acid interferes with amino acid transfer from aminoacyl-tRNA to protein on the ribosomes. Fusidic acid is active against a wide range of gram-positive organisms. The sustained release formulation ensures prolonged contact with the conjunctival sac. Fusidic acid penetrates well into the aqueous humor.
Fusidic acid is a bacteriostatic antibiotic and helps prevent bacterial growth while the immune system clears the infection.
| Trade Name | Fusidic Acid Sinphar |
| Generic | Fusidic Acid |
| Fusidic Acid Other Names | Acide fusidique, Acido fusidico, Acidum fusidicum, Fucidate, Fucidin acid, Fusidate, Fusidic acid, Fusidine, Ramycin |
| Type | |
| Formula | C31H48O6 |
| Weight | Average: 516.7092 Monoisotopic: 516.345089268 |
| Protein binding | 97 to 99% |
| Groups | Approved, Investigational |
| Therapeutic Class | Miscellaneous Antibiotics |
| Manufacturer | |
| Available Country | Taiwan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Fusidic Acid Sinphar is used for the topical treatment of superficial bacterial infections of the eye and its adnexa. These may include - bacterial conjunctivitis, blepharoconjunctivitis, blepharitis, sty and keratitis. It may also be used for the management of corneal and conjunctival abrasions and foreign body injuries.
Fusidic Acid Sinphar is also used to associated treatment for these conditions: Bacterial Conjunctivitis, Eye and eyelid infections, Fungal skin infection, Skin Infections caused by Corynebacterium minutissimum infection, Skin Infections caused by Staphylococcus Aureus, Skin Infections caused by Streptococcus Infection, Skin Infections, Bacterial, Stye, Cutaneous dermatophyte infection, Eczematous rash, Mild Atopic dermatitis, Mild Dermatitis caused by Staphylococcus aureusis, Moderate Atopic dermatitis, Moderate Dermatitis caused by Staphylococcus aureusis, Ocular bacterial infections, Susceptible Bacterial Infections
How Fusidic Acid Sinphar works
Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.
Dosage
Fusidic Acid Sinphar dosage
Adults and children (≥ 2 years): Instill one drop in the affected eye(s) twice daily for 7 days. Treatment should be continued for at least 48 hours after the eye returns to normal.
Side Effects
Fusidic acid is generally associated with very few adverse effects. The most frequently reported treatment-related side-effect is slight stinging or irritation.
Precaution
- For ophthalmic use only
- To avoid possible contamination of the drops, do not touch the tube nozzle or to any surface
- Do not wear contact lenses during the treatment
- If more than one topical eye drug is being used, the drugs should be administered at least five (5) minutes interval between applications
Interaction
Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.
Food Interaction
- Take with food. Food reduces irritation.
Elimination Route
Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.
Half Life
Approximately 5 to 6 hours in adults.
Pregnancy & Breastfeeding use
Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Fusidic acid should be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.
Use in lactation: It is not clear if enough medication from the eye drop would pass into breast milk. Caution should be exercised while giving this eye drops to a nursing mother
Contraindication
Fusidic acid viscous eye drops is contraindicated in patients who are hypersensitive to any component of Fusidic Acid Sinphar (Eye Drops).
Special Warning
Use in children: Safety & effectiveness in children below the age of 2 years have not been established.
Storage Condition
Store between 2-25°C. Discard 1 mth after opening.
Innovators Monograph
You find simplified version here Fusidic Acid Sinphar
FAQ
What is Fusidic Acid Sinphar used for?
Fusidic Acid Sinphar is an antibiotic that is often used topically in creams and eyedrops but may also be given systemically as tablets or injections. The global problem of advancing antimicrobial resistance has led to a renewed interest in its use recently. Fusidic Acid Sinphar cream should be used on the skin. The cream is used for the local treatment of skin infections caused by bacteria that are sensitive to Fusidic Acid Sinphar such as impetigo (a weeping, crusty and swollen patch of skin), folliculitis, sycosis barbae, paronychia, erythrasma.
How safe is Fusidic Acid Sinphar?
There is inadequate evidence of safety in human pregnancy. Animal studies and many years of clinical experience suggest that Fusidic Acid Sinphar is devoid of teratogenic effects (birth defects), but Fusidic Acid Sinphar can cross the placental barrier.
How does Fusidic Acid Sinphar work?
Fusidic Acid Sinphar works by stopping the growth of the germs causing the infection.
What are the common side effects of Fusidic Acid Sinphar?
Common side effects of Fusidic Acid Sinphar are include:
- Skin rashes.
- Skin itching.
- Pain, stinging, burning sensation or redness of skin on application.
- Contact dermatitis.
Is Fusidic Acid Sinphar safe during pregnancy?
It's safe to use Fusidic Acid Sinphar cream, ointment or eye drops while you're pregnant. Very little of the medicine gets to your baby, and the small amount that does will not harm them.
Is Fusidic Acid Sinphar safe during breastfeeding?
Fusidic Acid Sinphar cream can be used during breastfeeding but it is recommended to avoid applying Fusidic Acid Sinphar cream on the breast.
Is Fusidic Acid Sinphar cream safe for babies?
Using Fusidic Acid Sinphar cream topically and breast-feeding is unlikely to harm your baby.
Can I use Fusidic Acid Sinphar daily?
Apply a small amount to the affected area 2 to 3 times daily for 7 to 14 days. If your doctor has directed you to cover the lesion with a gauze dressing, you may be directed to apply the medication only 1 or 2 times daily.
How long does Fusidic Acid Sinphar stay in my system?
The usual treatment time is up to 2 weeks. You should notice your skin improve after just a few days of using the cream. If there is no improvement after 7 days you should stop using the cream and go back to your doctor.
Is Fusidic Acid Sinphar good for acne?
Topical Fusidic Acid Sinphar is occasionally used as a treatment for acne vulgaris. As a treatment for acne, Fusidic Acid Sinphar is often partially effective at improving acne symptoms.
How often can I use Fusidic Acid Sinphar ?
It's usual to put on Fusidic Acid Sinphar cream or ointment 3 or 4 times a day.
What happens if I miss a dose of Fusidic Acid Sinphar?
If you forget to apply this Fusidic Acid Sinphar, apply it as soon as you remember. If it is almost time for your next application, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Who should not take Fusidic Acid Sinphar?
Fusidic Acid Sinphar topical products should not be used If you have allergic to Fusidic Acid Sinphar and its salts or to any of the ingredients of this medication.
When can I stop using Fusidic Acid Sinphar ?
Treatment should be stopped after 7 days if your skin has not improved after using Fusidic Acid Sinphar cream.
What happen if I take too much Fusidic Acid Sinphar?
If you apply too much Fusidic Acid Sinphar cream, it is unlikely to cause any harm. However, if you notice any effect or are worried, contact your doctor or pharmacist.
Is Fusidic Acid Sinphar a strong antibiotic?
Fusidic Acid Sinphar is a steroidal antibiotic and the only marketed member of the fusidane class.
Is Fusidic Acid Sinphar an antifungal?
Fusidic Acid Sinphar showed that compound 7 had strongest antifungal activity.
Is Fusidic Acid Sinphar good for pimples?
Topical Fusidic Acid Sinphar is occasionally used as a treatment for acne vulgaris. As a treatment for acne, Fusidic Acid Sinphar is often partially effective at improving pimples.
Can Fusidic Acid Sinphar be used for cold sores?
No, Fusidic Acid Sinphar is inapplicable on cold sores.
Is Fusidic Acid Sinphar cream good for cuts?
Fusidic Acid Sinphar is made to be put directly on skin and wounds.
