Ganite

Ganite Uses, Dosage, Side Effects, Food Interaction and all others data.

Ganite is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. This condition may occur when individuals develop various types of cancer. Ganite is also known by the common brand name Ganite.

Ganite exerts hypocalcemic effect by inhibiting calcium resorption from bone, possibly by stabilizing bone matrix, thereby reducing increased bone turnover. Ganite inhibits the growth of various lymphoma cell lines in vitro and exhibits antitumor activity in patients with lymphoma. The mechanism(s) of cytotoxicity is (are) only partly understood but appears to involve a two-step process: (1) targeting of gallium to cells, and (2) acting on multiple, specific intracellular processes. Gallium shares certain chemical properties with iron; therefore, it binds avidly to the iron transport protein transferrin. Transferrin-gallium complexes preferentially target cells that express transferrin receptors on their surface. Expression of transferrin receptors is particularly high on lymphoma cells. Cellular uptake of the gallium-transferrin complex leads to inhibition of cellular proliferation primarily via disruption of iron transport and homeostasis and blockade of ribonucleotide reductase. Recent studies have shown that cellular uptake of gallium leads to activation of caspases and induction of apoptosis. In phase II trials in patients with relapsed or refractory lymphoma, the antitumor activity of gallium nitrate is similar to, or better than, that of other commonly used chemotherapeutic agents.

Ganite
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Ganite
Generic	Gallium nitrate
Type	On, solution, concentrate
Formula	GaN₃O₉
Weight	Average: 255.738 Monoisotopic: 254.889034525
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	United States,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Ganite is a medication indicated for cancer-related hypercalcemia.

For the treatment of hypercalcemia. Also intended for the treatment of non-hodgkin's lymphoma.

Ganite is also used to associated treatment for these conditions: Symptomatic Hypercalcemia of malignancy

How Ganite works

Ganite is believed to exert a hypocalcemic effect by inhibiting calcium resorption from bone. Ganite localizes preferentially where bone resorption and remodeling is occurring, and inhibits osteoclast activity. Inhibition of resorption may occur via a reduction in increased bone turnover. It seems to enhance hydroxyapatite function, inhibit osteocalcin, and inhibit the vacuolar ATPase on the osteoclast ruffled membrane. All these aid in the reduction of bone resorption.