Gastric
Gastric Uses, Dosage, Side Effects, Food Interaction and all others data.
Gastric acetate suppresses the effect of histamine on the parietal cells of the stomach (H2-receptor antagonist). This suppressive action is dose-dependent. As a result, the production and secretion, particularly of gastric acid, are reduced. Gastric acetate has no antiandrogenic effects and does not influence drug-metabolizing enzymes in the liver.
The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.
| Trade Name | Gastric |
| Generic | Roxatidine |
| Type | |
| Therapeutic Class | H2 receptor antagonist |
| Manufacturer | |
| Available Country | South Korea |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of disorders of the upper gastro intestinal region that are due to an excess of hydrochloric acid in the gastric juice, i.e. duodenal ulcers, benign gastric ulcers. Also for prophylaxis of recurrent gastric and duodenal ulcers
Dosage
Gastric dosage
Zollinger-Ellison syndrome:75 mg bid.
Gastro-oesophageal reflux disease:75 mg bid or 150 mg at bedtime for 6-8 wk.
Premedication before anaesthesia:75 mg in the evening on the day before surgery and repeated 2 hr before induction of anaesthesia. Alternatively, 150 mg once on the night before surgery.
Peptic ulcer:150 mg at bedtime or 75 mg bid daily for 4-6 wk. Maintenance: 75 mg at bedtime.
Gastritis:75 mg once daily in the evening.
Side Effects
Occasional headache, GI disturbances, gynaecomastia, alopecia, blood dyscrasias, pancreatitis, sleep disturbances, restlessness, rarely dizziness. Hypersensitivity reactions e.g. rash and itching reported occasionally. Changes in pulse rate and transient impairment of sexual drive. Possible increase in liver enzyme activity. May reduce leucocytes and/or thrombocytes.
Precaution
Renal and hepatic impairment, pregnancy. May mask the symptoms of gastric malignancy
Interaction
May affect serum levels of protease inhibitors.
Pregnancy & Breastfeeding use
Pregnancy category is not classified. Contraindications in lactation
Contraindication
Lactation, Porphyria
Special Warning
Renal Impairment:
Zollinger-Ellison syndrome:
- CrCl <20: 75 mg every 2 days.
- CrCl 20-50: 75 mg at bedtime.
Gastro-oesophageal reflux disease:
- CrCl <20: 75 mg every 2 days.
- CrCl 20-50: 75 mg at bedtime.
Peptic ulcer:
- CrCl <20: 75 mg every 2 days.
- CrCl 20-50: 75 mg at bedtime.
Gastritis:
- CrCl <20: 75 mg every 2 days.
- CrCl 20-50: 75 mg at bedtime.
Innovators Monograph
You find simplified version here Gastric
FAQ
What is Gastric used for?
Gastric is used to treat gastric ulcers, Zollinger Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis.
How does Gastric work?
Gastric blocks histamine secretion. It curbs the production of acid by parietal cells and digestive acids. This drug prevents the histamine from binding on parietal cell H2 receptors, thereby controlling the symptoms of gastrointestinal disorders.
What are the common side effects of Gastric?
The common side effects of Gastric are skin Rash, gastrointestinal Constipation, diarrhea, nausea and gastrointestinal disturbances. Central Nervous System: Weakness, headache, dizziness, restlessness and drowsiness.
Is Gastric safe during pregnancy?
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.Use is recommended only if clearly needed and the benefit outweighs the risk.
Is Gastric safe during breastfeeding?
This drug is known to increase prolactin levels. There are no data on galactorrhea and adverse effects with breastfeeding.Caution is recommended.
Can I take Gastric empty stomach?
Gastric may be taken with or without food. It can be taken once daily before bedtime or twice daily in the morning and before bedtime, as recommended.
How long does it take for Gastric to start work?
After taking Gastric orally, the effect occurs within one hour. The maximum effect is generally reached within one to three hours of taking it. However, it depends upon the dose. The action of the medicine lasts for about 10 to 12 hours.
Can I take alcohol with Gastric?
Alcohol does not interfere with the working of Gastric. But, you should avoid taking alcohol as it will further damage the stomach, delaying your recovery.
Is Gastric safe for long-term use?
There is limited data available on whether Gastric can be used for a long term or not, but it is a relatively safe medicine. You should take it for the duration advised by your doctor. Do not take over-the-counter Roxatidine for longer than 2 weeks unless advised by your doctor.
What is the effect of Gastric on the Kidneys?
Gastric may have mild side effects on the kidneys.
What is the effect of Gastric on the Liver?
Very few cases of side effects of Gastric on the liver have been reported.
What is the effect of Gastric on the Heart?
Gastric is completely safe for the heart.
Is Gastric safe?
Gastric is safe as it does not bear any side effects.
Can I drive after taking Gastric?
Gastric does not cause dizziness or sleep, so you can drive a vehicle or operate machinery also.
Who should not take Gastric?
Contraindicated in patients with absence of urination, gastric malignancy and hypersensitivity.
What is the dosage of Gastric?
The recommended dose of 150mg/day.
What happen if I overdose on Gastric?
A wide range of signs and symptoms can occur when a person overdoses, and everyone responds differently. Signs and symptoms depend on a variety of factors including:
- which substance (or substances) they took
- how much they took
- how they took it
- their state of health
- their age
- other factors.
