Gastroquinolone

Gastroquinolone Uses, Dosage, Side Effects, Food Interaction and all others data.

Gastroquinolone is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Gastroquinolone is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014.

Table Of contents

• Gastroquinolone
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Gastroquinolone
Generic	Finafloxacin
Finafloxacin Other Names	Finafloxacin, gastrochinolon, gastroquinolone
Type
Formula	C20H19FN4O4
Weight	Average: 398.394 Monoisotopic: 398.139033271
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Gastroquinolone is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1 year and older.

Gastroquinolone is also used to associated treatment for these conditions: Acute Otitis Externa

How Gastroquinolone works

Gastroquinolone is a fluoroquinolone antibiotic, which selectively inhibit bacterial type II topoisomerase enzymes, DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair and recombination.

Toxicity

-Gastroquinolone was shown to be genotoxic and clastogenic in vitro, with and without metabolic activation, and in vivo. -General toxicity studies in rats have confirmed sperm toxicity following oral and intravenous dosing. -At 500 mg/kg/day, males were completely infertile, presumably due to low sperm count and sperm immobility.

Innovators Monograph

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