GC-376
GC-376 Uses, Dosage, Side Effects, Food Interaction and all others data.
GC-376 is a 3C-like protease (3CL pro or M pro) inhibitor that stops the cleavage and activation of functional viral proteins required for replication and transcription in host cells. The compound is known as a direct acting antiviral (DAA) for coronaviruses, and was initially developed using structure-guided design to combat MERS-Cov infections. In addition, GC-376 displays potent activity against various coronaviruses such as feline, ferret, and mink M pro. A prodrug of GC-373, GC-376 has recently been used to test inhibition of SARS-Cov-2 M pro. These results suggest that GC-376, and its metabolites may have therapeutic potential for Covid-19.
| Trade Name | GC-376 |
| Generic | GC-376 free acid |
| GC-376 free acid Other Names | GC-376 |
| Type | |
| Formula | C21H31N3O8S |
| Weight | Average: 485.55 Monoisotopic: 485.183186144 |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Innovators Monograph
You find simplified version here GC-376
