Гексален Uses, Dosage, Side Effects and more

An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects.

Гексален is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Гексален has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.

Trade Name	Гексален
Availability	Discontinued
Generic	Altretamine
Altretamine Other Names	Altretamin, Altretamina, Altrétamine, Altretamine, Altretaminum, Hexamethylmelamine
Related Drugs	carboplatin, doxorubicin, cisplatin, paclitaxel, Avastin, Lynparza
Type
Formula	C₉H₁₈N₆
Weight	Average: 210.2794 Monoisotopic: 210.159294606
Protein binding	94%
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	Russia
Last Updated:	January 7, 2025 at 1:49 am

Uses

Гексален is an antineoplastic agent used in palliative treatment of persistent or recurrent ovarian cancer.

For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.

Гексален is also used to associated treatment for these conditions: Ovarian Cancer, Ovarian Cancer Stage III

How Гексален works

The precise mechanism by which altretamine exerts its cytotoxic effect is unknown although it is classified as an alkylating anti-neoplastic agent. Through this mechanism, the drug is metabolized into alkylating agents by N-demethylation. These alkylating species consequently damage tumor cells.