Gel-One
Gel-One Uses, Dosage, Side Effects, Food Interaction and all others data.
Sodium hyaluronate is a polysaccharide which functions as a tissue lubricant. It is widely used in ophthalmic surgery because it forms a viscoelastic solution in water which makes it a suitable substitute for aqueous and vitreous humour.
| Trade Name | Gel-One |
| Generic | Sodium Hyaluronate |
| Type | |
| Therapeutic Class | Drugs for Osteoarthritis |
| Manufacturer | |
| Available Country | USA |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Gel-One is used for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy, and to simple analgesics, e.g., acetaminophen.
Gel-One is a viscous solution consisting of a high molecular weight fraction of purified natural sodium hyaluronate in buffered physiological sodium phosphate. It has a pH of 5.5-7.0. Hyaluronic acid is an important component of the body's extracellular matrix and is present in a particularly high concentration in cartilage and synovial fluid. Endogenous hyaluronic acid provides viscosity and elasticity to synovial fluid, which is fundamental for its lubricating and shock absorbing properties. It is essential for the correct structure of proteoglycans in articular cartilage. In osteoarthritis there is an insufficient amount of and a chance in the quality of hyaluronic acid in synovial fluid and cartilage. The intra-articular administration of hyaluronic acid into arthritic joints with degenerating cartilage surfaces and pathologically altered synovial fluid improved functions.
Dosage
Gel-One dosage
Gel-One is administered by intra-articular injection. A treatment cycle consists of five injections given at weekly intervals. Some patients may experience benefit with three injections given at weekly intervals. Inject the full 2 ml in one knee only. If treatment is bilateral, a separate injection should be used for each knee.
Side Effects
The common side-effects include gastrointestinal complaints, injection site pain, knee swelling/effusion, local skin reactions (rash, ecchymosis), pruritus, and headache.
Precaution
Use caution when injecting Gel-One into patients who are allergic to avian proteins, feathers, and egg products. Strict aseptic administration technique must be followed. Remove joint effusion, if present, before injecting Gel-One. Do not use the same syringe for removing joint effusion and for injecting Gel-One. It is recommended that the patient avoid any strenuous activities or prolonged (i.e., more than 1 hour) weight-bearing activities such as jogging or tennis within 48 hours following the intra-articular injection.
Pregnancy & Breastfeeding use
The safety and effectiveness of Gel-One have not been established in pregnant women. It is not known if Gel-One is excreted in human milk. The safety and effectiveness of Gel-One have not been established in lactating mother. The safety and effectiveness of Gel-One have not been demonstrated in children.
Contraindication
The drug is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site.
Acute Overdose
No case of over dosage has been reported to date.
Storage Condition
Hyronate injection should be stored in a cool (below 25° C) and dry place and protected from light. Protect from freezing.
Innovators Monograph
You find simplified version here Gel-One
FAQ
What is Gel-One used for?
Gel-One topical skin medication is used to treat skin ulcers such as bed sores or diabetic foot ulcers, as well as burn wounds, surgical incisions, cuts, abrasions, and other skin irritations. Gel-One skin medication is also used to treat dry or scaly skin.
How safe is Gel-One?
Gel-One as well as are considered safe. It's rarely associated with side effects when applied topically.
How does Gel-One work?
Gel-One works by pulling in moisture from the environment and the underlying layers of your skin into the epidermis.
What are the common side effects of Gel-One?
The common side effects of Gel-One are include:
- warmth, pain, redness, stiffness, bruising, or puffiness where the medicine was injected;
- nausea, stomach pain;
- trouble walking;
- swelling in your hands or feet;
- back pain, joint pain, muscle pain;
- numbness or tingly feeling;
- headache, dizziness; or
- runny or stuffy nose, sneezing, sore throat.
How is Gel-One given?
Gel-One is injected directly into your knee joint. A healthcare provider will give you this injection.
Gel-One is usually given once every week for 3 to 5 weeks. Follow your doctor's dosing instructions very carefully.
Who should not take Gel-One?
You should not receive a Gel-One injection if you have an infection in your knee or in the skin around your knee.
Is Gel-One safe during pregnancy?
Gel-One also safe to use during pregnant.
Is Gel-One safe during breastfeeding?
It is not known whether Gel-One topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Is Gel-One safe for skin?
Gel-One are considered safe. It's rarely associated with side effects when applied topically.
How long take Gel-One?
Gel-One usually given once every week for 3 to 5 weeks.
How long does Gel-One last?
Gel-One lasts for about six months or longer in most people.
How much Gel-One should I take?
Doses of 120–240 mg per day for at least one month have been shown to significantly increase skin moisture and reduce dry skin in adults.
Does Gel-One have long term benefits?
Studies show that long term use is safe, with no reported side effects from Gel-One supplementation. Used as a topical skincare ingredient, Gel-One is also well tolerated.
Is it OK to use Gel-One every day?
Yes, you can even use it twice a day as long as you're applying it to clean, damp skin, then locking it in with a moisturizer and face oil.
What happens if you use too much Gel-One?
Too much Gel-One can leave skin thirstier, and dehydration lines more prominent.
Does Gel-One lighten dark spots?
Gel-One can also minimize age spots and prevent any dark spots in the future on your skin.
Can Gel-One dry skin?
Gel-One is one of the most hydrating ingredients, but if misused,Gel-One can actually dry out your skin.
Is Gel-One good for pimples?
While Gel-One can't fill in visible acne scars, it can help reduce redness and the visible appearance of acne.
Is Gel-One good for wrinkles?
Gel-One is well known for its skin benefits, especially alleviating dry skin, reducing the appearance of fine lines and wrinkles and speeding up wound healing.
Is Gel-One good for hair?
You can use Gel-One regardless of your hair type. It'll help your hair follicles lock in moisture.
Can I use Gel-One under eyes?
Yes you can.Gel-One can help mask darkness under the eyes.
What does Gel-One do to your face?
Gel-One helps reduce the visibility of fine lines and wrinkles retaining moisture to the skin.
Can Gel-One cause facial hair growth?
Gel-One is similar to a fertilizer because it can increase hair growth.
What happen If I missed Gel-One?
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
What happens if I overdose?
Gel-One may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing.call a poison control center right away.
