Gemeprost

Gemeprost Uses, Dosage, Side Effects, Food Interaction and all others data.

Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for termination of 1st- and 2nd-trimester pregnancy . It is not FDA-approved but available in Japan marketed as Preglandin.

Gemeprost softens and dilates of the cervix prior to transcervical intrauterine operative procedures. It is a prostaglandin E1 analog that potently stimulates uterine contractions and causes cervical ripening and relaxation .

Trade Name Gemeprost
Generic Gemeprost
Gemeprost Other Names Gemeprost, SC-37681
Type
Formula C23H38O5
Weight Average: 394.552
Monoisotopic: 394.271924324
Groups Approved, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Gemeprost
Gemeprost

Uses

Gemeprost is a prostaglandin E1 analogue used for cervical dilation and, in combination with mifepristone, for pregnancy termination.

Indicated for the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy or facilitating therapeutic termination of pregnancy in patients in the second trimester of gestation.

Gemeprost is also used to associated treatment for these conditions: Cervical Dilatation, Pregnancy termination therapy

How Gemeprost works

As a prostaglandin analog, gemeprost binds to prostaglandin E2 and E3 receptors as an agonist to cause myometrial contractions and progressive cervical dilation via tissue sensitization to oxytocin .

Toxicity

Serious or life-threatening adverse effects include coronary spasms with subsequent myocardial infarctions and uterine rupture following prolonged uterine hypertonia or abnormal uterine pain. More common adverse effects are nausea, vomiting, loose stools, diarrhea, lower abdominal or back pain, headache, mild pyrexia and flushing. Less common side effects include hypotension, chest pain palpitations, tachycardia, muscle weakness, dyspnea, chills and headache. Oral LD50 is 300 mg/kg in mouse, 980 mg/kg in rat and 3200 mg/kg in rabbit .

Elimination Route

Systemic absorption of gemeprost is limited with about 12-28% of administered dose of gemeprost reaching the systemic circulation . Following vaginal administration, peak plasma concentration is reached after 2-3 hours .

Elimination Route

About 50% of the dose eliminated as metabolites in the urine during the first 24 hours.

Innovators Monograph

You find simplified version here Gemeprost

*** Taking medicines without doctor's advice can cause long-term problems.
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