Gende

Gende Uses, Dosage, Side Effects, Food Interaction and all others data.

Gende is a first generation bisphosphonate similar to clodronic acid and tiludronic acid. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Etidronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate zoledronic acid, ibandronic acid, minodronic acid, and risedronic acid.

Gende was granted FDA approval on 1 September 1977.

Gende is a first generation bisphosphonate that inhibits the action of osteoclasts, preventing bone resporption. It has a wide therapeutic index as overdoses are not associated with severe toxicity and a long duration of action as it slowly releases from the bone. Patients should be counselled regarding the risk of upper gastrointestinal adverse reactions.

Trade Name Gende
Generic Etidronic acid
Etidronic acid Other Names Acetodiphosphonic acid, acide étidronique, ácido etidrónico, acidum etidronicum, EHDP, Etidronate, Etidronic acid, Etidronsäure, HEDP, Hydroxyethanediphosphonic acid, Oxyethylidenediphosphonic acid
Type
Formula C2H8O7P2
Weight Average: 206.0282
Monoisotopic: 205.974525634
Groups Approved
Therapeutic Class
Manufacturer
Available Country China
Last Updated: September 19, 2023 at 7:00 am
Gende
Gende

Uses

Gende is a bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis.

Etidronate is indicated to treat Paget's disease of bone, as well as the treatment and prevention of heterotropic ossification after total hip replacement of spinal cord injury.

Gende is also used to associated treatment for these conditions: Heterotopic Ossification (HO), Paget's Disease of Bone

How Gende works

Bisphosphonates are taken into the bone where they bind to hydroxyapatite. Bone resorption by osteoclasts causes local acidification, releasing the bisphosphonate, which is taken into the osteoclast by fluid-phase endocytosis. Endocytic vesicles become acidified, releasing bisphosphonates into the cytosol of osteoclasts where they act.

Osteoclasts mediate resorption of bone. When osteoclasts bind to bone they form podosomes, ring structures of F-actin. Disruption of the podosomes causes osteoclasts to detach from bones, preventing bone resorption.

First generation bisphosphonates closely mimic the structure of pyrophosphate, which can be incorporated into ATP anologues that cannot be hydrolyzed, disrupting all ATP mediated actions of osteoclasts.

Toxicity

Patients experiencing an overdose may present with hypocalcemia, vomiting, parasthesia, and diarrhea. Overdose can be treated with symptomatic and supportive treatment that may include management of electrolyte imbalances and intravenous calcium gluconate.

Food Interaction

  • Avoid multivalent ions. Separate administration from multivalent ions by at least two hours.
  • Take on an empty stomach.
  • Take with a full glass of water.

Volume of Distribution

Gende has a volume of distribution of 0.3-1.3L/kg.

Elimination Route

Gende has an oral bioavailability of 1-10%. Further data regarding pharmacokinetics of etidronic acid are not readily available.

Half Life

The half life of etidronate is approximately 1-6 hours.

Clearance

Gende has a renal clearance of 0.09L/kg/h.

Elimination Route

Absorbed etidronic acid is eliminated in the urine, while the unabsorbed drug is eliminated in the feces.

Innovators Monograph

You find simplified version here Gende

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000264
http://classyfire.wishartlab.com/tax_nodes/C0000419
http://classyfire.wishartlab.com/tax_nodes/C0000327
http://classyfire.wishartlab.com/tax_nodes/C0000327
http://classyfire.wishartlab.com/tax_nodes/C0001302
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000400
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4907
http://www.hmdb.ca/metabolites/HMDB0015210
http://www.genome.jp/dbget-bin/www_bget?drug:D02373
http://www.genome.jp/dbget-bin/www_bget?cpd:C07736
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3305
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507694
https://www.chemspider.com/Chemical-Structure.3189.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115102
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1356715
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=4907
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL871
https://zinc.docking.org/substances/ZINC000003830813
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DNC000629
http://www.pharmgkb.org/drug/PA449548
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/911
http://www.rxlist.com/cgi/generic/didronel.htm
https://en.wikipedia.org/wiki/Etidronic_acid
*** Taking medicines without doctor's advice can cause long-term problems.
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