Gentian Violet

Gentian Violet Uses, Dosage, Side Effects, Food Interaction and all others data.

In aqueous solutions Gentian violet (GV) dissociates into positive (GV+)and negative ions (Cl-) that penetrate through the wall and membrane of both gram-positive and gram-negative bacterial cells. The GV+ interacts with negatively charged components of bacterial cells including the lipopolysaccharide (on the cell wall), the peptidoglycan and DNA. A similar cell penetration and DNA binding process is thought to take place for fungal cells as well. Because Gentian violet is a mutagen and mitotic poison, cell growth is consequently inhibited. A photodynamic action of gentian violet, apparently mediated by a free-radical mechanism, has recently been described in bacteria and in the protozoan T. cruzi. Evidence also suggests that gentian violet dissipates the bacterial (and mitochondrial) membrane potential by inducing permeability. This is followed by respiratory inhibition. This anti-mitochondrial activity might explain gentian violet's efficacy towards both bacteria and yeast with relatively mild effects on mammalian cells.

Table Of contents

• Gentian Violet
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Gentian Violet
Generic	Gentian Violet
Weight	1%w/v, 2%, 100%,
Type	Solution, Topical Solution, Powder, Topical, Vaginal
Therapeutic Class	Crystal violet/ Gentian violet preparations
Manufacturer	Karachi Chemical Industries, Momotaz Pharmaceuticals Ltd, Chemist Laboratories Limited, Essential Drugs Company Ltd
Available Country	Pakistan, Bangladesh, United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Topical antiseptic as first aid to help prevent infection in minor cuts, scrapes and burns

Dosage

Gentian Violet dosage

Clean the affected area and apply a small amount of this product on the area 1 to 3 times daily. May be covered with a sterile bandage.

Side Effects

Redness, irritation, swelling or pain persists or increases of if infection occurs.

Precaution

Stop use if the condition persists or gets worse. Do not use longer than 1 week.

Interaction

There are no known drug interactions and none well documented.

Pregnancy & Breastfeeding use

Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category.

Contraindication

Do not apply to an ulcerative lesion as this may cause tattoing of the skin.

Innovators Monograph

You find simplified version here Gentian Violet