Gla Ad

Gla Ad Uses, Dosage, Side Effects, Food Interaction and all others data.

Safflower (Carthamus tinctorius L) is a herbaceous plant in the Asteraceae family. Extracted from the seeds of safflowers, safflower oil is a rich source of various saturated fatty acids, monounsaturated fatty acid (oleic acid) or essential n-6 polyunsaturated fatty acid (PUFA) linoleic acid , depending on the flower type. Safflower oil with a higher content of polyunsaturated fatty acids is more commonly used as an edible oil. The constituents of safflower oil also include alpha-tocopherol, gamma-tocopherol, and mixed Tocopherol . Safflower oil is approved for use as an indirect additive in food contact substances and is readily available as a food ingredient. Gamma linolenic acid (GLA) safflower oil is marketed as an over-the-counter dietary supplement.

Safflower oil contains n-6 polyunsaturated fatty acids (PUFAs) such as conjugated linoleic acid (CLA) which may have lipid-lowering and anti-inflammatory actions, as well as tocopherols. In a study of post-menopausal, obese women with type 2 diabetes, safflower oil supplementation was associated with improved metabolic endpoints including HbA1c, fasting glucose, insulin sensitivity estimated by QUICKI, HDL cholesterol, CRP, and adiponectin .

Trade Name Gla Ad
Generic Gamma Linolenic Acid + Safflower Oil + D-panthenol
Weight 0.5%, 1%
Type Lotion, Cream
Therapeutic Class
Manufacturer Dr Reddys Laboratories Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Gla Ad
Gla Ad

Uses

No approved therapeutic indications.

How Gla Ad works

Linoleic acid in safflower oil may decrease serum cholesterol levels by activating hepatic uptake and biliary excretion of serum cholesterol . Tocopherol in safflower oil is a radical scavenger with antioxidant properties.

Toxicity

The LD50 in rats is >5.0 g/kg following oral administration and >50 g/kg following intraperitoneal administration .

Volume of Distribution

No pharmacokinetic data available.

Elimination Route

Fatty acids and tocopherol from safflower oil are expected to undergo absorption within the digestive tract.

Half Life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Elimination Route

No pharmacokinetic data available.

Innovators Monograph

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