Glecaprevir And Pibrentasvir

Glecaprevir And Pibrentasvir Uses, Dosage, Side Effects, Food Interaction and all others data.

Glecaprevir is an inhibitor of the HCV NS3/4A protease, which is a viral enzyme necessary for the proteolytic cleavage of the HCV encoded polyprotein into mature forms of the NS3, NS4A, NS4B, NS5A, and NS5B proteins. These multifunctional proteins, including NS3, are essential for viral replication. The N-terminal of NS3 protein confers serine protease activity, whileThe C-terminus of NS3 encodes a DExH/D-box RNA helicase which hydyolyzes NTP as an energy source to unwind double-stranded RNA in a 3′ to 5′ direction during replication of viral genomic RNA. NS4A is a cofactor for NS3 that directs the localization of NS3 and modulates its enzymatic activities. Glecaprevir disrupts the intracellular processes of the viral life cycle through inhibiting the NS3/4A protease activity of cleaving downstream junctions of HCV polypeptide and proteolytic processing of mature structural protein.NS5A is a phosphoprotein that plays an essential role in replication, assembly and maturation of infectious viral proteins. The basal phosphorylated form of NS5A, which is maintained by C-terminal serine cluster, is key in ensuring its interaction with the viral capsid protein, or the core protein. By blocking this interaction, pibrentasvir inhibits the assembly of proteins and production of mature HCV particles. NS5A also interacts with viral and cellular proteins to form the HCV replicase complex, and supports the RNA replication of HCV

Trade Name Glecaprevir And Pibrentasvir
Generic Glecaprevir + Pibrentasvir
Weight 100mg + 40mg
Type Oral tablet
Therapeutic Class Hepatic viral infections (Hepatitis C)
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Glecaprevir And Pibrentasvir
Glecaprevir And Pibrentasvir

Uses

This is a fixed-dose combination of glecaprevir, a hepatitis C virus (HCV) NS3/4A protease inhibitor, and pibrentasvir, an HCV NS5A inhibitor, and is used for the treatment of patients with chronic HCV genotype (GT) 1, 2, 3, 4, 5 or 6 infection without cirrhosis and with compensated cirrhosis (Child-Pugh A). This is also used for the treatment of adult patients with HCV genotype 1 infection, who previously have been treated with a regimen containing an HCV NS5A inhibitor or an NS3/4A protease inhibitor, but not both.
Renal Impairment: No dosage adjustment is required in patients with mild, moderate or severe renal impairment, including those on dialysis

Hepatic Impairment: No dosage adjustment is required in patients with mild hepatic impairment (Child-Pugh A). This is not recommended in patients with moderate hepatic impairment (Child-Pugh B). Safety and efficacy have not been established in HCV-infected patients with moderate hepatic impairment. This is contraused for patients with sev.

Glecaprevir And Pibrentasvir is also used to associated treatment for these conditions: Chronic Hepatitis C Genotype 1, Chronic hepatitis C genotype 2, Chronic hepatitis C genotype 3, Chronic hepatitis C genotype 4, Chronic hepatitis C genotype 5, Genotype 6 chronic hepatitis C infection, Previously treated with an HCV regimen containing an NS3/4A protease inhibitor Chronic Hepatitis C Genotype 1, Previously treated with an HCV regimen containing an NS5A inhibitor Chronic Hepatitis C Genotype 1Chronic Hepatitis C Genotype 1, Chronic hepatitis C genotype 2, Chronic hepatitis C genotype 3, Chronic hepatitis C genotype 4, Chronic hepatitis C genotype 5, Genotype 6 chronic hepatitis C infection

How Glecaprevir And Pibrentasvir works

Glecaprevir is an inhibitor of the HCV NS3/4A protease, which is a viral enzyme necessary for the proteolytic cleavage of the HCV encoded polyprotein into mature forms of the NS3, NS4A, NS4B, NS5A, and NS5B proteins . These multifunctional proteins, including NS3, are essential for viral replication. The N-terminal of NS3 protein confers serine protease activity, whileThe C-terminus of NS3 encodes a DExH/D-box RNA helicase which hydyolyzes NTP as an energy source to unwind double-stranded RNA in a 3′ to 5′ direction during replication of viral genomic RNA . NS4A is a cofactor for NS3 that directs the localization of NS3 and modulates its enzymatic activities . Glecaprevir disrupts the intracellular processes of the viral life cycle through inhibiting the NS3/4A protease activity of cleaving downstream junctions of HCV polypeptide and proteolytic processing of mature structural proteins .

NS5A is a phosphoprotein that plays an essential role in replication, assembly and maturation of infectious viral proteins. The basal phosphorylated form of NS5A, which is maintained by C-terminal serine cluster, is key in ensuring its interaction with the viral capsid protein, or the core protein. By blocking this interaction, pibrentasvir inhibits the assembly of proteins and production of mature HCV particles . NS5A also interacts with viral and cellular proteins to form the HCV replicase complex, and supports the RNA replication of HCV .

Dosage

Glecaprevir And Pibrentasvir dosage

Testing Prior to the Initiation of Therapy: Test all patients for HBV infection by measuring HBsAg and anti-HBc.

Recommended dosage: Three tablets (total daily dose: glecaprevir 300 mg and pibrentasvir 120 mg) taken orally once daily with food.

See recommended treatment duration in tables below-

Treatment-Naïve Patients: HCV Genotype 1, 2, 3, 4, 5, or 6

  • No Cirrhosis: 8 weeks
  • Compensated Cirrhosis (Child-Pugh A): 12 weeks
Treatment-Experienced Patients: HCV Genotype 1
  • Patients Previously Treated With a Regimen Containing: An NS5A inhibitor without prior treatment with an NS3/4A protease inhibitor
  • No Cirrhosis: 16 weeks
  • Compensated Cirrhosis (Child-Pugh A): 16 weeks
Treatment-Experienced Patients: HCV Genotype 1
  • Patients Previously Treated With a Regimen Containing: An NS3/4A PI without prior treatment with an NS5A inhibitor
  • No Cirrhosis: 12 weeks
  • Compensated Cirrhosis (Child-Pugh A): 12 weeks
Treatment-Experienced Patients: HCV Genotype 1, 2, 4, 5 or 6
  • Patients Previously Treated With a Regimen Containing: PRS
  • No Cirrhosis: 8 weeks
  • Compensated Cirrhosis (Child-Pugh A): 12 weeks
Treatment-Experienced Patients: HCV Genotype 3
  • Patients Previously Treated With a Regimen Containing: PRS
  • No Cirrhosis: 16 weeks
  • Compensated Cirrhosis (Child-Pugh A): 16 weeks

Side Effects

In subjects receiving Glecaprevir And Pibrentasvir, the most commonly reported adverse reactions (greater than 10%) are headache and fatigue.

Toxicity

Glecaprevir is not shown to be genotoxic according to in vitro or in vivo studies. It also shows to have no effect on mating, female or male fertility, or early embryonic development in rodent studies. Carcinogenicity studies with glecaprevir have not been conducted .

Pibrentasvir is not shown to be genotoxic according to in vitro or in vivo studies. It also shows to have no effect on mating, female or male fertility, or early embryonic development in rodent studies. Carcinogenicity studies with pibrentasvir have not been conducted .

Precaution

Risk of Hepatitis B Virus Reactivation: Test all patients for evidence of current or prior HBV infection before initiation of HCV treatment. Monitor HCV/HBV coinfected patients for HBV reactivation and hepatitis flare during HCV treatment and post-treatment follow-up. Initiate appropriate patient management for HBV infection as clinically indicated.

Interaction

Carbamazepine, efavirenz, and St. John’s wort may decrease concentrations of glecaprevir and pibrentasvir. Coadministration of carbamazepine, efavirenz containing regimens, and St. John’s wort with this preparation is not recommended.

Elimination Route

In healthy subjects, the time it takes to reach the peak plasma concentration (Tmax) is approximately 5 hours. The mean peak plasma concentration (Cmax) is 597ng/mL in non-cirrhotic HCV-infected subjects. Relative to fasting conditions, the consumption of meals increases the absorption of glecaprevir by 83-163% .

In healthy subjects, the time it takes to reach the peak plasma concentration (Tmax) is approximately 5 hours. The mean peak plasma concentration (Cmax) is 110ng/mL in non-cirrhotic HCV-infected subjects. Relative to fasting conditions, the consumption of meals increases the absorption of pibrentasvir by 40-53% .

Half Life

The elimination half life (t1/2) is approximately 6 hours .

The elimination half life (t1/2) is approximately 13 hours .

Elimination Route

The predominant route of elimination of the drug is biliary-fecal, where 92.1% of administered drug is excreted in feces and 0.7% of the drug is excreted in the urine .

The predominant route of elimination of the drug is biliary-fecal, where 96.6% of administered drug is excreted in feces and 0% of the drug is excreted in the urine .

Pregnancy & Breastfeeding use

No adequate human data are available to establish whether or not Glecaprevir And Pibrentasvir poses a risk to pregnancy outcomes. It is not known whether the components of Glecaprevir And Pibrentasvir are excreted in human breast milk, affect human milk production, or have effects on the breastfed infant. When administered to lactating rodents, the components of Glecaprevir And Pibrentasvir were present in milk, without effect on growth and development observed in the nursing pups. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Glecaprevir And Pibrentasvir and any potential adverse effects on the breastfed child from Glecaprevir And Pibrentasvir or from the underlying maternal condition.

Contraindication

Patients with severe hepatic impairment (Child-Pugh C). Coadministration with atazanavir and rifampin

Acute Overdose

In case of overdose, the patient should be monitored for any signs and symptoms of toxicities. Appropriate symptomatic treatment should be instituted immediately. Glecaprevir and pibrentasvir are not significantly removed by hemodialysis.

Storage Condition

Store at or below 30°C

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