Gleolan

Gleolan Uses, Dosage, Side Effects, Food Interaction and all others data.

A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]

The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis. Gleolan is not a photosensitizer, but rather a metabolic precursor of protoporphyrin IX (PpIX), which is a photosensitizer. The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. ALA, when provided to the cell, bypasses this control point and results in the accumulation of PpIX, which is converted into heme by ferrochelatase through the addition of iron to the PpIX nucleus.

Trade Name Gleolan
Generic Aminolevulinic acid
Aminolevulinic acid Other Names 5-ALA, 5-Aminolevulinic acid, ácido 5-aminolevulínico, Aminolevulinic acid, dALA
Weight 30mg/ml,
Type Oral powder for reconstitution
Formula C5H9NO3
Weight Average: 131.1299
Monoisotopic: 131.058243159
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Gleolan
Gleolan

Uses

Gleolan is a porphyrin precursor used to treat actinic keratosis of the face, scalp, and upper extremities, as well as to visualize a glioma.

Gleolan plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.

Gleolan is also used to associated treatment for these conditions: Actinic Cheilitis, Actinic Keratoses of the face, Actinic Keratoses of the scalp, Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC)

How Gleolan works

According to the presumed mechanism of action, photosensitization following application of aminolevulinic acid (ALA) topical solution occurs through the metabolic conversion of ALA to protoporphyrin IX (PpIX), which accumulates in the skin to which aminolevulinic acid has been applied. When exposed to light of appropriate wavelength and energy, the accumulated PpIX produces a photodynamic reaction, a cytotoxic process dependent upon the simultaneous presence of light and oxygen. The absorption of light results in an excited state of the porphyrin molecule, and subsequent spin transfer from PpIX to molecular oxygen generates singlet oxygen, which can further react to form superoxide and hydroxyl radicals. Photosensitization of actinic (solar) keratosis lesions using aminolevulinic acid, plus illumination with the BLU-UTM Blue Light Photodynamic Therapy Illuminator (BLU-U), is the basis for aminolevulinic acid photodynamic therapy (PDT).

Toxicity

Solution overdose have not been reported.

Food Interaction

No interactions found.

Elimination Route

Oral bioavailability is 50-60%.

Half Life

Mean half-life is 0.70 ± 0.18 h after the oral dose and 0.83 ± 0.05 h after the intravenous dose.

Innovators Monograph

You find simplified version here Gleolan

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000264
http://classyfire.wishartlab.com/tax_nodes/C0000265
http://classyfire.wishartlab.com/tax_nodes/C0000013
http://classyfire.wishartlab.com/tax_nodes/C0001879
http://classyfire.wishartlab.com/tax_nodes/C0001115
http://classyfire.wishartlab.com/tax_nodes/C0001416
http://classyfire.wishartlab.com/tax_nodes/C0000122
http://classyfire.wishartlab.com/tax_nodes/C0004176
http://classyfire.wishartlab.com/tax_nodes/C0001137
http://classyfire.wishartlab.com/tax_nodes/C0001205
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0000469
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17549
http://www.lipidmaps.org/data/LMSDRecord.php?LMID=LMFA01100055
http://www.hmdb.ca/metabolites/HMDB0001149
http://www.genome.jp/dbget-bin/www_bget?cpd:C00430
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=137
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506856
https://www.chemspider.com/Chemical-Structure.134.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240386
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=155002
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=17549
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL601
https://zinc.docking.org/substances/ZINC000003782550
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000314
http://www.pharmgkb.org/drug/PA10015
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/FVT
http://www.rxlist.com/cgi/generic3/levulan.htm
https://www.drugs.com/cdi/aminolevulinic-acid-solution.html
https://en.wikipedia.org/wiki/Aminolevulinic_acid
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