Gloshine
Gloshine Uses, Dosage, Side Effects, Food Interaction and all others data.
Gloshine is a topical depigmentating agent that produces a reversible depigmentation of the skin by inhibiting enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine and suppressing melanocyte metabolic processes.
| Trade Name | Gloshine |
| Generic | Hydroquinone |
| Hydroquinone Other Names | 1,4-benzenediol, Hydroquinone, Quinol |
| Type | Cream |
| Formula | C6H6O2 |
| Weight | Average: 110.1106 Monoisotopic: 110.036779436 |
| Groups | Approved, Investigational |
| Therapeutic Class | Hydroquinone Preparations |
| Manufacturer | Scott Edil Pharmacia Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Gloshine is used -
- For the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other unwanted areas of melanin hyperpigmentation.
- To reduce hyperpigmentation caused by photosensitization associated with inflammation or with the use of certain cosmetics.
Gloshine is also used to associated treatment for these conditions: Acne Vulgaris, Melasma, Skin hyperpigmentation, Moderate Melasma, Severe Melasma
How Gloshine works
Gloshine reduces melanin pigment production through inhibition of the tyrosinase enzyme, which is involved in the initial step of the melanin pigment biosynthesis pathway. Gloshine takes several months to take effect.
Dosage
Gloshine dosage
Apply a thin film of Gloshine Cream to the effected area once daily, at least 30 minutes before bedtime. Gently wash the face and neck with a mild cleanser. Rinse and pat the skin dry. Apply Gloshine Cream to the hyperpigmented areas of melasma including about ½ inch of normal appearing skin surrounding eachlesion. Rub lightly and uniformly into the skin.
Therapy should be discontinued when control is achieved. During the day, use asunscreenof SPF 30, and wear protective clothing. Avoid sunlight exposure. Patients may use moisturizers and/or cosmetics during the day. Gloshine Cream is for topical use only. It is not for oral,ophthalmic, or intravaginal use.
Side Effects
No systemic adverse reactions have been reported. Occasional hypersensitivity (localized contact dermatitis) may occur in which case the medication should be discontinued.
Precaution
Gloshine is a skin bleaching agent which may produce unwanted cosmetic effects if not used as directed. The physician should be familiar with the contents of this insert before prescribing or dispensing this medication.
Test for skin sensitivity before using by applying a small amount to an unbroken patch of skin to check in 24 hours. Minor redness is not a contraindication, but where there is itching or vesicle formation or excessive inflammatory response, further treatment is not advised. If no bleaching or lightening effect is noted after 2 months of treatment, the medication should be discontinued.
Contact with the eyes and lips should be avoided. Gloshine should not be applied to cut or abraded skin.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Lactation: It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother.
Contraindication
Gloshine is contraindicated to patients with prior history of hypersensitivity or allergic reaction to hydroquinone or other ingredients in the preparation.
Acute Overdose
There have been no systemic reactions from the use of topical hydroquinone. Some patients may experience a transient reddening of skin and mild burning sensation which does not preclude treatment.
Storage Condition
Store between 20-25° C. Protect from light.
Innovators Monograph
You find simplified version here Gloshine
Gloshine contains Hydroquinone see full prescribing information from innovator Gloshine Monograph, Gloshine MSDS, Gloshine FDA label
FAQ
What is Gloshine used for?
Gloshine is used to lighten the dark patches of skin (also called hyperpigmentation, melasma, "liver spots," "age spots," freckles) caused by pregnancy, birth control pills, hormone medicine, or injury to the skin. Gloshine also known as benzene-1,4-diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula C₆H₄(OH)₂. It has two hydroxyl groups bonded to a benzene ring in a para position.
How safe is Gloshine?
Gloshine is deemed safe in the United States. There isn't any clinical evidence currently to suggest that Gloshine is harmful to humans. However, minor side effects are still possible. It may cause a temporary uptick in redness or dryness at first, especially if you have sensitive skin.
How does Gloshine work?
Gloshine bleaches your skin by decreasing the number of melanocytes present.
What are the common side effects of Gloshine?
Common side effects of Gloshine include:
- Mild skin irritation and sensitization (burning, stinging)
- Dermatitis.
- Dryness.
- Redness.
- Inflammatory reaction.
Is Gloshine safe during pregnancy?
Whitening and brightening solutions with Gloshine are safe to use during pregnancy and won't harm the foetus.
Is Gloshine safe during breastfeeding?
Gloshine is not contraindicated during breastfeeding and if Gloshine is required by the mother, it is not a reason to discontinue breastfeeding. However, some experts feel that long-term use of Gloshine is difficult to justify in a nursing mother.
Can Gloshine make me blind?
Inhaling Gloshine can irritate the nose and throat.
Is Gloshine hazardous?
Gloshine is also a skin irritant in humans. Chronic (long-term) occupational exposure to Gloshine dust can result in eye irritation, corneal effects, and impaired vision.
Can I leave Gloshine on overnight?
Apply Gloshine cream once daily to clean, dry skin, preferably at bedtime, and leave on overnight.
Can I use Gloshine everyday?
Gloshine a tyrosinase inhibitor, in a 4% cream can be used safely twice daily for up to 6 months to treat post-inflammatory hyperpigmentation. The efficacy of this treatment can be enhanced by using a retinoid nightly and a mid-potent steroid, which is applied twice daily for 2 weeks, then at weekends only.
How fast does Gloshine work?
It takes about four weeks on average for the ingredient to take effect.
How long should I use Gloshine?
You can use the product for up to four months, and then begin to taper off use.
Can Gloshine be used in the morning?
Apply Gloshine in the evening after Retin-A and in the morning for 2 to 6 weeks prior to the procedure.
How often can I use Gloshine?
Gloshine a tyrosinase inhibitor, in a 4% cream can be used safely twice daily for up to 6 months to treat post-inflammatory hyperpigmentation.
How long does Gloshine take to work?
Gloshine takes about four weeks on average for the ingredient to take effect.
Can I take Gloshine for long time?
You shouldn't use products with this ingredient for more than five months at a time.
When should I stop taking Gloshine?
Gloshine stop application after five months. If your skin lightens, stop using Gloshine regularly and only use it if the dark spots reappear. Wait two or three months to use it in the same areas.
Who should not take Gloshine?
Do not use Gloshine topical on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. Call your doctor if your symptoms do not improve after 2 months, or if your condition gets worse.
What happens if I miss a dose?
Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.
What happens if I overdose of Gloshine?
An overdose of Gloshine topical is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication.
What happen If I stop taking Gloshine?
Prolonged regular use of Gloshine may lead to exogenous ochronosis, which can cause blue-black pigmentation and papules, red bumps on the skin.
Is Gloshine hard on my heart?
Gloshine can cause dangerous effects on your heart, especially if you also use certain other medicines. Seek emergency medical attention if you have fast or pounding heartbeats and sudden dizziness
Can Gloshine affect my kidneys?
Gloshine produce significant histological alterations that might affect the liver and kidney.
Can Gloshine affects my liver?
Gloshine can remove the top layer of skin, increasing the risk of skin cancer and cause fatal liver and kidney damage.
