Glubionate Calcium

Uses

Calcium glubionate is a calcium salt indicated in the treatment of hypocalcemia, hyperkalemia, lead poisoning, and as an adjunct in the treatment of exudative skin conditions.

Calcium glubionate is indicated to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).

Glubionate Calcium is also used to associated treatment for these conditions: Calcium Deficiency, Exudative skin conditions, Fluoride Poisoning, Hypocalcemia, Severe hyperkalemia

How Glubionate Calcium works

Essential for nervous, muscular, and skeletal systems. Maintain cell membrane and capillary permeability. Act as an activator in the transmission of nerve impulses and contraction of cardiac, skeletal, and smooth muscle. Essential for bone formation and blood coagulation.

Toxicity

Assess patient for nausea, vomiting, anorexia, thirst, severe constipation, paralytic ileus, and bradycardia

Volume of Distribution

Primarily in bones, teeth

Elimination Route

Minimal unless chronic, high doses; absorption predominantly in the duodenum and dependent on calcitriol and vitamin D; mean absorption of calcium intake varies with age (infants 60%, prepubertal children 28%, pubertal children 34%, adults 25%); during pregnancy, calcium absorption doubles; calcium is absorbed in soluble, ionized form; solubility of calcium is increased in an acid environment (IOM 2011); decreased absorption occurs in patients with achlorhydria, renal osteodystrophy, steatorrhea, or uremia

Elimination Route

Primarily feces (75%; as unabsorbed calcium); urine (22%)

Innovators Monograph

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