Glucosamine Sulfate + Chondroitin + Camphor + Peppermint oil

Uses

This pain-relieving cream is applied topically and provides powerful pain relief of osteoarthritis pain, sprains, simple backache, tendonitis, minor arthritis pain.

Glucosamine Sulfate + Chondroitin + Camphor + Peppermint oil is also used to associated treatment for these conditions: Arthritis, Backache, Common Cold, Contusions, Inflammatory Reaction caused by Insect Bites, Joint Pain, Muscle Cramps, Nasal Congestion, Pain caused by Insect Bites, Rash, Skin Irritation, Soreness, Muscle, Sunburn, Swelling caused by Insect Bites, Minor burns, Neck or back pain, Shoulder acheColic, Cough, Flatulence, Hypertonicity of the small intestine, Irritable Bowel Syndrome (IBS), Mild pain, Nasal Congestion, Soreness, Muscle, Gas pain

How Glucosamine Sulfate + Chondroitin + Camphor + Peppermint oil works

Dose-dependent antispasmodic effect of peppermint oil is largely mediated by its menthol constituent . It is proposed that peppermint oil relaxes gastrointestinal smooth muscle and attenuates contractile responses by reducing the influx of extracellular calcium ions. In rabbit jejunum smooth muscle cells investigated via whole cell clamp configuration technique, peppermint oil was shown to inhibit the potential-dependent calcium currents in a concentration-dependent manner . Both a reduction in peak current amplitude and an increase in the rate of current decay were observed, indicating that the pharmacological activity peppermint oil resembles that of dihydropyridine calcium antagonists . In a rat small intestine study, peppermint oil in the intestinal lumen inhibited enterocyte glucose uptake via a direct action on the brush border membrane and inhibited intestinal secretion . There is also evidence that menthol is an antagonist of L-type Ca2+ channels via interacting with dihydropyridine binding sites and blocks the currents of low-voltage-activated calcium channels . Peppermint oil may facilitate hair growth by promoting the conservation of vascularization of hair dermal papilla, which may contribute to the induction of early anagen stage of active growth phase of hair follicles .

Dosage

Glucosamine Sulfate + Chondroitin + Camphor + Peppermint oil dosage

For the management of osteoarthritis the recommended dose is twice daily into painful muscle and joints for 2-4 week. Apply gently to painful muscles and joints, until this pain relieving cream disappears. Repeat as necessary.

Side Effects

There are no known systemic side effects unless people have an allergy or skin sensitivity to camphor or one of the inactive ingredients.

Toxicity

Oral LD50 value in rat is 2426 mg/kg . In fasted mice, the LD50 following oral administration was 2410 mg/kg . Higher doses of peppermint oil has the potential to induce menstruation, bronchospasm, tongue spasms, and, possibly, respiratory arrest in addition to potential hepatotoxicity and nephrotoxicity .

Overdose may cause severe gastrointestinal symptoms, diarrhoea, rectal ulceration, epileptic convulsions, loss of consciousness, apnoea, nausea, disturbances in cardiac rhythms, ataxia and other CNS problems, probably due to the presence of menthol . In the event of overdose, the stomach should be emptied by gastric lavage. Observation should be carried out with symptomatic treatment if necessary . A near fatal case of high dose peppermint oil ingestion was reported, the overdose was characterized by comatose and reduced heart rate .

Precaution

Do not apply on broken or irritated skin or if excessive irritation develops. Do not bandage tightly or use a heating pad. Do not swallow. Avoid eye contact or mucous membranes.

Interaction

This medicine is not known to interact significantly with other medicines.

Volume of Distribution

No pharmacokinetic data available.

Elimination Route

After oral administration, peppermint is rapidly absorbed . Menthol is highly fat-soluble therefore rapidly absorbed from the proximal gut .

Half Life

No pharmacokinetic data available.

Clearance

No pharmacokinetic data available.

Elimination Route

Peppermint oil is eliminated mainly via the bile following oral administration, with glucuronide and sulphate metabolites predominant . The metabolites, mainly menthol glucuronide and mono- or di-hydroxylated menthol derivatives, may also undergo approximately equal renal and fecal excretion . Renal recovery of total menthol within 24 hours was dose-dependent whereas the recovery in bile was substantially higher over 8 hours .

Pregnancy & Breastfeeding use

It should not be used during pregnancy & lactation.

Contraindication

Contraindicated in patients with achlorhydria. Also contraindicated for infants due to the potential risk of spasm of the tongue or respiratory arrest.

Storage Condition

Store in a cool and dry place, away from light. keep out of reach of children.

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