Glutethimide

Glutethimide Uses, Dosage, Side Effects, Food Interaction and all others data.

Glutethimide is a hypnotic and sedative. Its use has been largely superseded by other drugs.

Glutethimide, like the barbiturates, is a hypnotic sedative. It was introduced in 1954 as a safer alternative to barbiturates but was soon determined to be just as likely to cause addiction and withdrawal symptoms.

Table Of contents

• Glutethimide
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Glutethimide
Generic	Glutethimide
Glutethimide Other Names	Glutethimide, Glutetimida
Type
Formula	C13H15NO2
Weight	Average: 217.2637 Monoisotopic: 217.110278729
Groups	Approved, Illicit
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment of insomnia.

How Glutethimide works

Glutethimide seems to be a GABA agonist which helps induce sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of codeine (higher than the average 5 - 10%) to morphine. This combination of effects enhances sedation.

Toxicity

In adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported.

Food Interaction

• Avoid alcohol.
• Take with or without food. The absorption is unaffected by food.

Elimination Route

Variable

Half Life

10-12 hours

Elimination Route

glutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces.

Innovators Monograph

You find simplified version here Glutethimide