Glyceryl Triheptanoate

Glyceryl Triheptanoate Uses, Dosage, Side Effects, Food Interaction and all others data.

Glyceryl Triheptanoate is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation. In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, rhabdomyolysis, and hepatomegaly. Complications in lc-FAOD patients are reduced from approximately 60% to approximately 10% with the addition of triheptanoin.

Glyceryl Triheptanoate was granted FDA approval on 30 June 2020.

Glyceryl Triheptanoate is a source of medium chain fatty acids for patients with lc-FAODs. It has a moderate duration of action and a wide therapeutic window. Patients should be counselled regarding the risk of feeding tube dysfunction and intestinal malabsorption due to pancreatic insufficiency.

Table Of contents

• Glyceryl Triheptanoate
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Glyceryl Triheptanoate
Availability	Prescription only
Generic	Triheptanoin
Triheptanoin Other Names	Glycerol triheptanoate, Glyceryl triheptanoate, Trienanthoin, Triheptanoic glyceride, Triheptanoin, Triheptylin, Trioenanthoin
Related Drugs	Dojolvi
Type
Formula	C24H44O6
Weight	Average: 428.61 Monoisotopic: 428.313789137
Protein binding	Triheptanoin is approximately 80% protein bound in plasma, likely serum albumin.
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Glyceryl Triheptanoate is triheptanoin is a medium chain triglyceride indicated to provide calories and fatty acids to treat long chain fatty acid oxidation disorders.

Glyceryl Triheptanoate is a medium chain triglyceride indicated to provide calories and fatty acids to treat long chain fatty acid oxidation disorders (lc-FAODs).

Glyceryl Triheptanoate is also used to associated treatment for these conditions: Long-chain Fatty Acid Oxidation Disorders (LC-FAOD)

How Glyceryl Triheptanoate works

Glyceryl Triheptanoate is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation. In clinical trials, patients with lc-FAODs treated with triheptanoin experienced improvements in hypoglycemia, cardiomyopathy, and rhabdomyolysis.

Food Interaction

• Take with food. Take triheptanoin with food, liquid, or formula.

Elimination Route

A single 0.3 g/kg dose of triheptanoin reaches a C_max of 178.9 µmol/L, with a T_max 0.5 h, and an AUC of 336.5 µmol*h/L. A single 0.4 g/kg dose of triheptanoin reaches a C_max of 259.1 µmol/L, with a T_max 0.8 h, and an AUC of 569.1 µmol*h/L.

Half Life

Due to multiple peak concentrations of the heptanoate metabolite, the half life of triheptanoin could not be determined.

Clearance

A single dose of 0.3 g/kg results in a mean apparent clearance of 6.05 L/h/kg for heptanoate. A single dose of 0.4 g/kg results in a mean apparent clearance of 4.31 L/h/kg for heptanoate.

Elimination Route

Glyceryl Triheptanoate is minimally eliminated in the urine.

Innovators Monograph

You find simplified version here Glyceryl Triheptanoate